Evidence map›Paper›PMID 34299032›Full record

ArticleInternational journal of molecular sciences2021

Butyrate Feeding Reverses CypD-Related Mitoflash Phenotypes in Mouse Myofibers.

Ang Li, Xuejun Li, Jianxun Yi, Jianjie Ma, Jingsong Zhou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Role of the Mitochondrial Permeability Transition in Bone Metabolism and Aging.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023
    Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ang LiDepartment of Kinesiology, College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, TX 76010, USA.ORCID 0000-0002-8784-4702
Xuejun LiDepartment of Kinesiology, College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, TX 76010, USA.
Jianxun YiDepartment of Kinesiology, College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, TX 76010, USA.
Jianjie MaDepartment of Surgery, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA.
Jingsong ZhouDepartment of Kinesiology, College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, TX 76010, USA.
The University of Texas at Arlington · USLung Institute · US

Funding

MG53 function in muscle agingR01AG071676 · NIA · UNIVERSITY OF VIRGINIA · PI Jianjie Ma, Ki Ho Park · 2022 to 2026
$3.1M
Preserving Mitochondrial Function for Alleviating ALS ProgressionR01NS105621 · NINDS · UNIVERSITY OF TEXAS ARLINGTON · PI BROTTO, MARCO, ZHOU, JINGSONG · 2019 to 2023
$2.9M
NIA NIH HHS R01 AG071676NIH HHS R01NS105621NINDS NIH HHS R01 NS105621U.S. Department of Defense AL170061
6 · The paper itself

Abstract

Mitoflashes are spontaneous transients of the biosensor mt-cpYFP. In cardiomyocytes, mitoflashes are associated with the cyclophilin D (CypD) mediated opening of mitochondrial permeability transition pore (mPTP), while in skeletal muscle they are considered hallmarks of mitochondrial respiration burst under physiological conditions. Here, we evaluated the potential association between mitoflashes and the mPTP opening at different CypD levels and phosphorylation status by generating three CypD derived fusion constructs with a red shifted, pH stable Ca

Indexed as

MutationAnimalsButyratesFemaleHumansMaleMiceMice, TransgenicMitochondriaMitochondrial Permeability Transition PoreMuscle Fibers, SkeletalPeptidyl-Prolyl Isomerase FSuperoxide Dismutase-1ButyratesMitochondrial Permeability Transition PorePeptidyl-Prolyl Isomerase FSOD1 protein, humanSuperoxide Dismutase-1amyotrophic lateral sclerosisbutyratecyclopilin DjRCaMP1bmPTPsupervised inspection of Ca2+ transients

Identifiers

PMID34299032
PMCPMC8304904
OpenAlexW3178170981

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.