Evidence map›Paper›PMID 34299027›Full record

ArticleInternational journal of molecular sciences2021

Megalin, Proton Pump Inhibitors and the Renin-Angiotensin System in Healthy and Pre-Eclamptic Placentas.

Yuan Sun, Lunbo Tan, Rugina I Neuman, Michelle Broekhuizen, Sam Schoenmakers, Xifeng Lu, A H Jan Danser

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Atypical Preeclampsia before 20 Weeks of Gestation-A Systematic Review.International journal of molecular sciences · 2023
    Pooled it
  2. Review
  3. Article
  4. Placental Related Disorders of Pregnancy.International journal of molecular sciences · 2022
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Yuan SunDivision of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, 3015 CN Rotterdam, The Netherlands.
Lunbo TanDivision of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, 3015 CN Rotterdam, The Netherlands.
Rugina I NeumanDivision of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, 3015 CN Rotterdam, The Netherlands.
Michelle BroekhuizenDivision of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, 3015 CN Rotterdam, The Netherlands.ORCID 0000-0002-4736-398X
Sam SchoenmakersDepartment of Obstetrics and Gynaecology, Erasmus MC, 3015 CN Rotterdam, The Netherlands.
Xifeng LuHealth Science Center, Department of Physiology, Shenzhen University, Shenzhen 518061, China.
A H Jan DanserDivision of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, 3015 CN Rotterdam, The Netherlands.ORCID 0000-0002-5052-3585
Erasmus MC · NLShenzhen University Health Science Center · CN

Funding

National Natural Science Foundation of China 81800383National Natural Science Foundation of China 81870605Shenzhen Key Laboratory of Metabolism and Cardiovascular Homeostasis ZDSYS20190902092903237Shenzhen Municipal Science and Technology Innovation Council JCYJ20170817093928508Shenzhen Municipal Science and Technology Innovation Council JCYJ20190808170401660
6 · The paper itself

Abstract

Soluble Fms-like tyrosine kinase-1 (sFlt-1) is increased in pre-eclampsia. The proton pump inhibitor (PPI) lowers sFlt-1, while angiotensin increases it. To investigate whether PPIs lower sFlt-1 by suppressing placental renin-angiotensin system (RAS) activity, we studied gene expression and protein abundance of RAS components, including megalin, a novel endocytic receptor for prorenin and renin, in placental tissue obtained from healthy pregnant women and women with early-onset pre-eclampsia.

Indexed as

Renin-Angiotensin SystemAdultCase-Control StudiesFemaleHumansLow Density Lipoprotein Receptor-Related Protein-2PlacentaPre-EclampsiaPregnancyProton Pump InhibitorsVascular Endothelial Growth Factor Receptor-1FLT1 protein, humanLow Density Lipoprotein Receptor-Related Protein-2LRP2 protein, humanProton Pump InhibitorsVascular Endothelial Growth Factor Receptor-1megalinpre-eclampsiaproton pump inhibitorsrenin–angiotensin system

Identifiers

PMID34299027
PMCPMC8306182
OpenAlexW3181490698

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.