Evidence map›Paper›PMID 34299024›Full record

SynthesisInternational journal of molecular sciences2021

Mechanisms of Action and Efficacy of Hyaluronic Acid, Corticosteroids and Platelet-Rich Plasma in the Treatment of Temporomandibular Joint Osteoarthritis-A Systematic Review.

Marcin Derwich, Maria Mitus-Kenig, Elzbieta Pawlowska

Registry-linked trialOpen access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05817162 (Comparison of Temporomandibular Joint Arthrocentesis With Infiltration of PRP + Ropivacaine Versus PRP), which is not on this map. Cited by 67 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 9 pooled it
19.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05817162 phase4unknown statusnot on this mapstarted 2023, after this paper: background citation

Comparison of Temporomandibular Joint Arthrocentesis With Infiltration of PRP + Ropivacaine Versus PRP: Does It Reduce Postoperative Pain?

TypeinterventionalSponsorInstituto Portugues da FaceRan2023 to 2024Enrolled30ConditionsTemporomandibular Joint DisordersArmsRopivacaine injection, temporomandibular joint arthrocentesis, PRP injection, Ringer's Lactate solution
3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 9 syntheses or guidelines pooled it, 121 citations in OpenAlex.

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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Marcin DerwichORTODENT, Specialist Orthodontic Private Practice in Grudziadz, 86-300 Grudziadz, Poland.ORCID 0000-0002-7203-271X
Maria Mitus-KenigDepartment of Experimental Dentistry and Prophylaxis, Medical College, Jagiellonian University in Krakow, 31-008 Krakow, Poland.
Elzbieta PawlowskaDepartment of Orthodontics, Medical University of Lodz, 90-419 Lodz, Poland.ORCID 0000-0002-5373-4783
Jagiellonian University · PLMedical University of Lodz · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Temporomandibular joint osteoarthritis (TMJ OA) is a low-inflammatory disorder with multifactorial etiology. The aim of this review was to present the current state of knowledge regarding the mechanisms of action and the efficacy of hyaluronic acid (HA), corticosteroids (CS) and platelet-rich plasma (PRP) in the treatment of TMJ OA.: The PubMed database was analyzed with the keywords: "(temporomandibular joint) AND ((osteoarthritis) OR (dysfunction) OR (disorders) OR (pain)) AND ((treatment) OR (arthrocentesis) OR (arthroscopy) OR (injection)) AND ((hyaluronic acid) OR (corticosteroid) OR (platelet rich plasma))". After screening of 363 results, 16 studies were included in this review. Arthrocentesis alone effectively reduces pain and improves jaw function in patients diagnosed with TMJ OA. Additional injections of HA, either low-molecular-weight (LMW) HA or high-molecular-weight (HMW) HA, or CS at the end of the arthrocentesis do not improve the final clinical outcomes. CS present several negative effects on the articular cartilage. Results related to additional PRP injections are not consistent and are rather questionable. Further studies should be multicenter, based on a larger group of patients and should answer the question of whether other methods of TMJ OA treatment are more beneficial for the patients than simple arthrocentesis.

Indexed as

AdolescentAdrenal Cortex HormonesAdultHumansHyaluronic AcidInjections, Intra-ArticularOsteoarthritisPlatelet-Rich PlasmaSignal TransductionTemporomandibular Joint DisordersAdrenal Cortex HormonesHyaluronic Acidarthrocentesiscorticosteroidshyaluronic acidintraarticular injectionsplatelet-rich plasmatemporomandibular joint disorderstemporomandibular joint osteoarthritis

Identifiers

PMID34299024
PMCPMC8308010
OpenAlexW3179619667

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.