Evidence map›Paper›PMID 34299009›Full record

ArticleInternational journal of molecular sciences2021

Influence of Cannabinoid Receptor 1 Genetic Variants on the Subjective Effects of Smoked Cannabis.

Thomas Murphy, Justin Matheson, Robert E Mann, Bruna Brands, Christine M Wickens, Arun K Tiwari, Clement C Zai, James Kennedy, Bernard Le Foll

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Cannabis use disorder: from neurobiology to treatment.The Journal of clinical investigation · 2024
    Review
  4. Cannabis Pharmacogenomics: A Path to Personalized Medicine.Current issues in molecular biology · 2023
    Review
  5. Review
  6. Association betweenBrain sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Thomas MurphyCentre for Addiction and Mental Health, Translational Addiction Research Laboratory, University of Toronto, 33 Ursula Franklin Street, Toronto, ON M5S 2S1, Canada.
Justin MathesonDepartment of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada.ORCID 0000-0001-6248-3704
Robert E MannCentre for Addiction and Mental Health, Institute for Mental Health Policy Research, Toronto, ON M6J 1H4, Canada.
Bruna BrandsDepartment of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada.
Christine M WickensDepartment of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada.ORCID 0000-0002-9865-850X
Arun K TiwariNeurogenetics Section, Tanenbaum Centre for Pharmacogenetics, Molecular Brain Science, Campbell Family Mental Health Research Institute, CAMH, Toronto, ON M5T 1R8, Canada.
Clement C ZaiNeurogenetics Section, Tanenbaum Centre for Pharmacogenetics, Molecular Brain Science, Campbell Family Mental Health Research Institute, CAMH, Toronto, ON M5T 1R8, Canada.
James KennedyNeurogenetics Section, Tanenbaum Centre for Pharmacogenetics, Molecular Brain Science, Campbell Family Mental Health Research Institute, CAMH, Toronto, ON M5T 1R8, Canada.
Bernard Le FollCentre for Addiction and Mental Health, Translational Addiction Research Laboratory, University of Toronto, 33 Ursula Franklin Street, Toronto, ON M5S 2S1, Canada.ORCID 0000-0002-6406-4973
Centre for Addiction and Mental Health · CABroad Institute · USHealth Canada · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As many jurisdictions consider relaxing cannabis legislation and usage is increasing in North America and other parts of the world, there is a need to explore the possible genetic differences underlying the subjective effects of cannabis. This pilot study investigated specific genetic variations within the cannabinoid receptor 1 (

Indexed as

AdultAffectAllelesArea Under CurveCannabinoidsCannabisFemaleGenotypeHumansMaleMarijuana SmokingPilot ProjectsPolymorphism, Single NucleotideReceptor, Cannabinoid, CB1CannabinoidsCNR1 protein, humanReceptor, Cannabinoid, CB1cannabisCNR1 genesubjective effectsΔ9-tetrahydrocannabinol

Identifiers

PMID34299009
PMCPMC8307475
OpenAlexW3156372962

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.