Evidence map›Paper›PMID 34298987›Full record

ArticleInternational journal of molecular sciences2021

Allosteric Modulation of GSK-3β as a New Therapeutic Approach in Limb Girdle Muscular Dystrophy R1 Calpain 3-Related.

Anabel Rico, Garazi Guembelzu, Valle Palomo, Ana Martínez, Ana Aiastui, Leire Casas-Fraile, Andrea Valls, Adolfo López de Munain, Amets Sáenz

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. GSK-3β Allosteric Inhibition: A Dead End or a New Pharmacological Frontier?International journal of molecular sciences · 2023
    Review
  11. New Pharmacological Approaches for Rare Diseases.International journal of molecular sciences · 2023
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Anabel RicoBiodonostia Health Research Institute, Neurosciences Area, 20014 San Sebastian, Spain.ORCID 0000-0002-3002-6688
Garazi GuembelzuBiodonostia Health Research Institute, Neurosciences Area, 20014 San Sebastian, Spain.
Valle PalomoSpanish Ministry of Economy & Competitiveness, Carlos III Health Institute, CIBERNED, 28031 Madrid, Spain.ORCID 0000-0002-1473-4086
Ana MartínezSpanish Ministry of Economy & Competitiveness, Carlos III Health Institute, CIBERNED, 28031 Madrid, Spain.ORCID 0000-0002-2707-8110
Ana AiastuiBiodonostia Health Research Institute, Cell Culture and Histology Platform, 20014 San Sebastian, Spain.
Leire Casas-FraileBiodonostia Health Research Institute, Neurosciences Area, 20014 San Sebastian, Spain.ORCID 0000-0002-7504-6578
Andrea VallsBiodonostia Health Research Institute, Neurosciences Area, 20014 San Sebastian, Spain.ORCID 0000-0002-9211-4034
Adolfo López de MunainBiodonostia Health Research Institute, Neurosciences Area, 20014 San Sebastian, Spain.ORCID 0000-0002-9509-4032
Amets SáenzBiodonostia Health Research Institute, Neurosciences Area, 20014 San Sebastian, Spain.ORCID 0000-0002-0704-1150
Instituto de Salud Carlos III · ESBiogipuzkoa Health Research Institute · ESUniversity of the Basque Country · ES

Funding

Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas CB18/05/00040Department of Education, Universities and Research of the Basque Government PRE-2016-1-0382GENE (Association of Neuromuscular diseases of Gipuzkoa) Without numberHealth Research Fund of the Spanish Ministry of Economy and Competitiveness and the European Union (ERDF) PI16/01325, PI17/01841 and DTS19/00061
6 · The paper itself

Abstract

Limb-girdle muscular dystrophy R1 calpain 3-related (LGMDR1) is an autosomal recessive muscular dystrophy produced by mutations in the

Indexed as

Adenosine TriphosphateAllosteric SiteCalpainCD56 AntigenFibroblastsGene Expression RegulationGlycogen Synthase Kinase 3 betaHumansHydrazinesIntracellular Signaling Peptides and ProteinsMuscle Fibers, SkeletalMuscle ProteinsMuscular Dystrophies, Limb-GirdleNerve Tissue ProteinsPhosphorylationProtein Processing, Post-TranslationalAdenosine TriphosphateAKT1 protein, humanCalpainCAPN3 protein, humanCD56 AntigenGlycogen Synthase Kinase 3 betaHydrazinesIntracellular Signaling Peptides and ProteinsMTOR protein, humanMuscle ProteinsNCAM1 protein, humanNerve Tissue ProteinsProto-Oncogene Proteins c-aktQuinolonessmall molecule VP 0.7ThiadiazolestideglusibTOR Serine-Threonine KinasesCAPN3GSK-3βLGMDR1limb-girdle muscular dystrophymTORtideglusibVP0.7Wnt

Identifiers

PMID34298987
PMCPMC8308041
OpenAlexW3181171672

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.