Evidence map›Paper›PMID 34298983›Full record

ArticleInternational journal of molecular sciences2021

Transfection of Vitamin D3-Induced Tolerogenic Dendritic Cells for the Silencing of Potential Tolerogenic Genes. Identification of CSF1R-CSF1 Signaling as a Glycolytic Regulator.

María José Mansilla, Iñigo González-Larreategui, Neus Figa-Martín, Jaume Barallat, Federico Fondelli, Ares Sellés-Rius, Bibiana Quirant-Sánchez, Aina Teniente-Serra, Eva Martínez-Cáceres

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

María José MansillaDivision of Immunology, Germans Trias i Pujol University Hospital and Research Institute, Campus Can Ruti, 08916 Badalona, Spain.ORCID 0000-0002-5044-6313
Iñigo González-LarreateguiDivision of Immunology, Germans Trias i Pujol University Hospital and Research Institute, Campus Can Ruti, 08916 Badalona, Spain.ORCID 0000-0002-0959-8497
Neus Figa-MartínDivision of Immunology, Germans Trias i Pujol University Hospital and Research Institute, Campus Can Ruti, 08916 Badalona, Spain.
Jaume BarallatDepartment of Biochemistry, Germans Trias i Pujol University Hospital, 08916 Badalona, Spain.ORCID 0000-0003-3493-5958
Federico FondelliDivision of Immunology, Germans Trias i Pujol University Hospital and Research Institute, Campus Can Ruti, 08916 Badalona, Spain.
Ares Sellés-RiusDivision of Immunology, Germans Trias i Pujol University Hospital and Research Institute, Campus Can Ruti, 08916 Badalona, Spain.ORCID 0000-0002-9745-7749
Bibiana Quirant-SánchezDivision of Immunology, Germans Trias i Pujol University Hospital and Research Institute, Campus Can Ruti, 08916 Badalona, Spain.
Aina Teniente-SerraDivision of Immunology, Germans Trias i Pujol University Hospital and Research Institute, Campus Can Ruti, 08916 Badalona, Spain.
Eva Martínez-CáceresDivision of Immunology, Germans Trias i Pujol University Hospital and Research Institute, Campus Can Ruti, 08916 Badalona, Spain.ORCID 0000-0002-6762-8025
Universitat Autònoma de Barcelona · ESHospital Universitari Germans Trias i Pujol · ES

Funding

Horizon 2020 779316Plan Nacional de I + D + I and co-supported by the ISCIII-Subdirección General de Evaluación and the Fondo Europeo de Desarrollo Regional (FEDER) PI17/01521 and PI20/01313
6 · The paper itself

Abstract

The use of autologous tolerogenic dendritic cells (tolDC) has become a promising strategy to re-establish immune tolerance in autoimmune diseases. Among the different strategies available, the use of vitamin D3 for the generation of tolDC (VitD3-tolDC) has been widely tested because of their immune regulatory properties. To identify molecules and pathways involved in the generation of VitD3-tolDC, we established an easy and fast gene silencing method based on the use of Viromer blue to introduce siRNA into monocytes on day 1 of culture differentiation. The analysis of the effect of

Indexed as

Cells, CulturedCholecalciferolCoculture TechniquesCulture Media, ConditionedDendritic CellsGlucoseGlycolysisHumansHydrogen-Ion ConcentrationImmune ToleranceInterleukinsLactatesLeukocytes, MononuclearMacrophage Colony-Stimulating FactorMonocytesReceptor, Macrophage Colony-Stimulating FactorCholecalciferolCSF1 protein, humanCSF1R protein, humanCulture Media, ConditionedGlucoseIL34 protein, humanInterleukinsLactatesMacrophage Colony-Stimulating FactorReceptor, Macrophage Colony-Stimulating FactorReceptors, Granulocyte-Macrophage Colony-Stimulating FactorautoimmunityCSF1RDC-SIGNtolerancetolerogenic dendritic cellsvitamin D3

Identifiers

PMID34298983
PMCPMC8305050
OpenAlexW3182374951

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.