Evidence map›Paper›PMID 34298979›Full record

ArticleInternational journal of molecular sciences2021

Platelet and Erythrocyte Extravasation across Inflamed Corneal Venules Depend on CD18, Neutrophils, and Mast Cell Degranulation.

Angie De La Cruz, Aubrey Hargrave, Sri Magadi, Justin A Courson, Paul T Landry, Wanyu Zhang, Fong W Lam, Monica A Bray, C Wayne Smith, Alan R Burns and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. The crucial role of thromboxane AFrontiers in pharmacology · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. An Epithelial Abrasion Model for Studying Corneal Wound Healing.Journal of visualized experiments : JoVE · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Angie De La CruzCollege of Optometry, University of Houston, Houston, TX 77204, USA.
Aubrey HargraveCollege of Optometry, University of Houston, Houston, TX 77204, USA.
Sri MagadiCollege of Optometry, University of Houston, Houston, TX 77204, USA.
Justin A CoursonCollege of Optometry, University of Houston, Houston, TX 77204, USA.
Paul T LandryCollege of Optometry, University of Houston, Houston, TX 77204, USA.
Wanyu ZhangCollege of Optometry, University of Houston, Houston, TX 77204, USA.
Fong W LamChildren's Nutrition Center, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0003-2034-2625
Monica A BrayChildren's Nutrition Center, Baylor College of Medicine, Houston, TX 77030, USA.
C Wayne SmithChildren's Nutrition Center, Baylor College of Medicine, Houston, TX 77030, USA.
Alan R BurnsCollege of Optometry, University of Houston, Houston, TX 77204, USA.
Rolando E RumbautChildren's Nutrition Center, Baylor College of Medicine, Houston, TX 77030, USA.
University of Houston · USMichael E. DeBakey VA Medical Center · USChildren's Nutrition Research Center at Baylor College of Medicine · US

Funding

Research Programming ModuleP30EY007551 · NEI · UNIVERSITY OF HOUSTON · PI GEUNYOUNG YOON · 1988 to 2026
$16.4M
OCULAR SURFACE INJURY: INFLAMMATORY CASCADE AND HEALING OF CORNEAL WOUNDSR01EY018239 · NEI · BAYLOR COLLEGE OF MEDICINE · PI BURNS, ALAN R, RUMBAUT, ROLANDO E · 2008 to 2020
$3.7M
Collaborative Research Training in Thrombosis and InflammationT32HL139425 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Miguel Angel Cruz, ROLANDO E RUMBAUT · 2018 to 2026
$2.4M
Platelets and Their Microparticles in the Inflamed MicrocirculationR01HL116524 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI BURNS, ALAN R, RUMBAUT, ROLANDO E · 2013 to 2017
$1.8M
Platelets and microvascular thrombosis in inflammationI01BX002551 · VA · MICHAEL E DEBAKEY VA MEDICAL CENTER · PI RUMBAUT, ROLANDO E · 2016 to 2025
–
BLRD VA I01 BX002551NEI NIH HHS EY018239NEI NIH HHS P30 EY007551NEI NIH HHS P30EY007551NEI NIH HHS R01 EY018239NHLBI NIH HHS HL116524NHLBI NIH HHS T32 HL139425University of Houston summer Vision Research Student GrantU.S. Department of Veterans Affairs Merit Review Award I01 BX002551
6 · The paper itself

Abstract

Platelet extravasation during inflammation is under-appreciated. In wild-type (WT) mice, a central corneal epithelial abrasion initiates neutrophil (PMN) and platelet extravasation from peripheral limbal venules. The same injury in mice expressing low levels of the β

Indexed as

Cell DegranulationAnimalsBlood PlateletsCD18 AntigensCell MovementChemotaxis, LeukocyteCorneaCorneal InjuriesEpithelium, CornealErythrocytesFemaleHyperemiaMacrophagesMaleMast CellsMiceCD18 Antigensextravasationinflammationplatelets

Identifiers

PMID34298979
PMCPMC8329926
OpenAlexW3181155608

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.