Evidence map›Paper›PMID 34298973›Full record

ArticleInternational journal of molecular sciences2021

How to Obtain a Mega-Intestine with Normal Morphology: In Silico Modelling of Postnatal Intestinal Growth in a Cd97-Transgenic Mouse.

Felix Hofmann, Torsten Thalheim, Karen Rother, Marianne Quaas, Christiane Kerner, Jens Przybilla, Gabriela Aust, Joerg Galle

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Adhesion G protein-coupled receptors.Pharmacological reviews · 2026
    Review
  2. Riding the Wave of Ambivalence in Cell Biology.International journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Felix HofmannResearch Laboratories, Department of Surgery, Leipzig University, 04107 Leipzig, Germany.
Torsten ThalheimInterdisciplinary Institute for Bioinformatics (IZBI), Leipzig University, 04107 Leipzig, Germany.ORCID 0000-0001-5489-7405
Karen RotherResearch Laboratories, Department of Surgery, Leipzig University, 04107 Leipzig, Germany.
Marianne QuaasResearch Laboratories, Department of Surgery, Leipzig University, 04107 Leipzig, Germany.
Christiane KernerResearch Laboratories, Department of Surgery, Leipzig University, 04107 Leipzig, Germany.
Jens PrzybillaInstitute for Medical Informatics, Statistics and Epidemiology (IMISE), Leipzig University, 04107 Leipzig, Germany.
Gabriela AustResearch Laboratories, Department of Surgery, Leipzig University, 04107 Leipzig, Germany.
Joerg GalleInterdisciplinary Institute for Bioinformatics (IZBI), Leipzig University, 04107 Leipzig, Germany.
Leipzig University · DE

Funding

Bundesministerium für Bildung und Forschung 031A312
6 · The paper itself

Abstract

Intestinal cylindrical growth peaks in mice a few weeks after birth, simultaneously with crypt fission activity. It nearly stops after weaning and cannot be reactivated later. Transgenic mice expressing

Indexed as

Computer SimulationModels, BiologicalAnimalsIntestinal MucosaIntestine, SmallKruppel-Like Factor 4MiceMice, TransgenicOrgan Culture TechniquesReceptors, G-Protein-CoupledStem CellsAdgre5 protein, mouseKlf4 protein, mouseKruppel-Like Factor 4Receptors, G-Protein-CoupledAregCd97contact inhibition of growthcrypt fissioncrypt formationfate decisionindividual cell-based modelKlf4mega-intestinepostnatal developmentstem cell fate

Identifiers

PMID34298973
PMCPMC8305140
OpenAlexW3180790333

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.