Evidence map›Paper›PMID 34298934›Full record

ArticleInternational journal of molecular sciences2021

Determination of Diosmin in Pharmaceutical Products with Chemically Modified Voltammetric Sensors.

Ramona Oana Gunache Roșca, Constantin Apetrei

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ramona Oana Gunache RoșcaDepartment of Chemistry, Physics and Environment, Faculty of Sciences and Environment, "Dunarea de Jos" University of Galati, 47 Domneasca Street, 800008 Galati, Romania.
Constantin ApetreiDepartment of Chemistry, Physics and Environment, Faculty of Sciences and Environment, "Dunarea de Jos" University of Galati, 47 Domneasca Street, 800008 Galati, Romania.ORCID 0000-0002-3823-4174
"Dunarea de Jos" University of Galati · RO

Funding

ANTREPRENORDOC Contract number 36355/23.05.2019 POCU/380/6/13 - SMIS code: 123847
6 · The paper itself

Abstract

In this paper, the electrochemical behavior of two types of sensors based on modified screen-printed electrodes (one screen-printed electrode based on carbon (SPCE) and another screen-printed electrode modified with Prussian Blue (PB/SPCE)) was studied with the aim of sensitive detection of diosmin, an active pharmaceutical compound from the class of flavonoids. The scan electron microscopy technique was used for the morphological characterization of PB/SPCE. The preliminary analysis assessed the electrochemical behavior of SPCE and PB/SPCE in KCl solution and in a double solution of potassium ferrocyanide-potassium chloride. It was shown that the active area of PB/SPCE is superior to the one of SPCE, the greater sensitivity being related with the presence of the electroactive modifier. Similarly, in the case of diosmin detection, the PB/SPCE sensor detect more sensitivity the diosmin due to the electrocatalytic effect of PB. From the study of the influence of reaction rate on the sensor's electrochemical response, it was shown that the detection process is controlled by the adsorption process, the degree of surface coverage with electroactive molecules being higher in the case of PB/SPCE. From the PB/SPCE calibration curve, it wasdetermined that it has high sensitivity and low detection and quantification limit values (limit of detection 5.22 × 10

Indexed as

CarbonDiosminElectrochemical TechniquesElectrodesLimit of DetectionPharmaceutical PreparationsSensitivity and SpecificityCarbonDiosminPharmaceutical Preparationscyclic voltammetrydiosminpharmaceutical productsensor

Identifiers

PMID34298934
PMCPMC8304735
OpenAlexW3180990588

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.