Evidence map›Paper›PMID 34298930›Full record

ArticleInternational journal of molecular sciences2021

Upregulation of Anti-Oxidative Stress Response Improves Metabolic Changes in L-Selectin-Deficient Mice but Does Not Prevent NAFLD Progression or Fecal Microbiota Shifts.

Sreepradha Eswaran, Anshu Babbar, Hannah K Drescher, Thomas C A Hitch, Thomas Clavel, Moritz Muschaweck, Thomas Ritz, Daniela C Kroy, Christian Trautwein, Norbert Wagner and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Sreepradha EswaranDepartment of Pediatrics, Faculty of Medicine, RWTH Aachen University, D-52074 Aachen, Germany.
Anshu BabbarDepartment of Pediatrics, Faculty of Medicine, RWTH Aachen University, D-52074 Aachen, Germany.
Hannah K DrescherDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0001-9945-1239
Thomas C A HitchFunctional Microbiome Research Group, Faculty of Medicine, RWTH Aachen University, D-52074 Aachen, Germany.
Thomas ClavelFunctional Microbiome Research Group, Faculty of Medicine, RWTH Aachen University, D-52074 Aachen, Germany.
Moritz MuschaweckDepartment of Pediatrics, Faculty of Medicine, RWTH Aachen University, D-52074 Aachen, Germany.
Thomas RitzInstitute of Pathology, Ruprecht-Karls-University Heidelberg, D-69117 Heidelberg, Germany.
Daniela C KroyDepartment of Internal Medicine III, University Hospital, RWTH Aachen, D-52074 Aachen, Germany.
Christian TrautweinDepartment of Internal Medicine III, University Hospital, RWTH Aachen, D-52074 Aachen, Germany.
Norbert WagnerDepartment of Pediatrics, Faculty of Medicine, RWTH Aachen University, D-52074 Aachen, Germany.
Angela SchippersDepartment of Pediatrics, Faculty of Medicine, RWTH Aachen University, D-52074 Aachen, Germany.
RWTH Aachen University · DEHarvard University · USHeidelberg University · DEUniversity of Calgary · CA

Funding

Deutsche Forschungsgemeinschaft 403224013 - SFB 1382
6 · The paper itself

Abstract

(1) Background: Non-alcoholic fatty liver disease (NAFLD) is a growing global health problem. NAFLD progression involves a complex interplay of imbalanced inflammatory cell populations and inflammatory signals such as reactive oxygen species and cytokines. These signals can derive from the liver itself but also from adipose tissue or be mediated via changes in the gut microbiome. We analyzed the effects of a simultaneous migration blockade caused by L-selectin-deficiency and an enhancement of the anti-oxidative stress response triggered by hepatocytic Kelch-like ECH-associated protein 1 (Keap1) deletion on NAFLD progression. (2) Methods: L-selectin-deficient mice (Lsel

Indexed as

AnimalsDiet, WesternFecesGastrointestinal MicrobiomeHepatocytesKelch-Like ECH-Associated Protein 1LiverL-SelectinMaleMiceMice, Inbred C57BLNF-E2-Related Factor 2Non-alcoholic Fatty Liver DiseaseOxidative StressReactive Oxygen SpeciesSignal TransductionKelch-Like ECH-Associated Protein 1L-SelectinNF-E2-Related Factor 2Reactive Oxygen Speciescellular migrationKeap1L-selectinmicrobiotaNAFLDNrf2oxidative stresswestern diet

Identifiers

PMID34298930
PMCPMC8306675
OpenAlexW3179835925

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.