Evidence map›Paper›PMID 34298899›Full record

ArticleInternational journal of molecular sciences2021

Adhesion of Triple-Negative Breast Cancer Cells under Fluorescent and Soft X-ray Contact Microscopy.

Paulina Natalia Osuchowska, Przemysław Wachulak, Wiktoria Kasprzycka, Agata Nowak-Stępniowska, Maciej Wakuła, Andrzej Bartnik, Henryk Fiedorowicz, Elżbieta Anna Trafny

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Paulina Natalia OsuchowskaBiomedical Engineering Centre, Institute of Optoelectronics, Military University of Technology, Kaliskiego 2, 00-908 Warsaw, Poland.ORCID 0000-0003-4715-6486
Przemysław WachulakLaser Technology Division, Institute of Optoelectronics, Military University of Technology, Kaliskiego 2, 00-908 Warsaw, Poland.ORCID 0000-0001-9853-7946
Wiktoria KasprzyckaBiomedical Engineering Centre, Institute of Optoelectronics, Military University of Technology, Kaliskiego 2, 00-908 Warsaw, Poland.ORCID 0000-0002-2796-2555
Agata Nowak-StępniowskaBiomedical Engineering Centre, Institute of Optoelectronics, Military University of Technology, Kaliskiego 2, 00-908 Warsaw, Poland.ORCID 0000-0002-8483-9780
Maciej WakułaMaria Sklodowska-Curie National Research Institute of Oncology, Roentgena 5, 02-781 Warsaw, Poland.ORCID 0000-0001-8673-909X
Andrzej BartnikLaser Technology Division, Institute of Optoelectronics, Military University of Technology, Kaliskiego 2, 00-908 Warsaw, Poland.
Henryk FiedorowiczMaria Sklodowska-Curie National Research Institute of Oncology, Roentgena 5, 02-781 Warsaw, Poland.ORCID 0000-0002-7022-3408
Elżbieta Anna TrafnyBiomedical Engineering Centre, Institute of Optoelectronics, Military University of Technology, Kaliskiego 2, 00-908 Warsaw, Poland.ORCID 0000-0003-0318-1698

Funding

Narodowym Centrum Nauki 2016/23/G/ST2/04319the European Union under the Horizon2020 Programme, Laserlab-Europe Project, 871124
6 · The paper itself

Abstract

Understanding cancer cell adhesion could help to diminish tumor progression and metastasis. Adhesion mechanisms are currently the main therapeutic target of TNBC-resistant cells. This work shows the distribution and size of adhesive complexes determined with a common fluorescence microscopy technique and soft X-ray contact microscopy (SXCM). The results presented here demonstrate the potential of applying SXCM for imaging cell protrusions with high resolution when the cells are still alive in a physiological buffer. The possibility to observe the internal components of cells at a pristine and hydrated state with nanometer resolution distinguishes SXCM from the other more commonly used techniques for cell imaging. Thus, SXCM can be a promising technique for investigating the adhesion and organization of the actin cytoskeleton in cancer cells.

Indexed as

Actin CytoskeletonCell AdhesionCell Line, TumorFemaleHumansMicroscopy, FluorescenceTriple Negative Breast NeoplasmsX-Raysadhesioncancer cellsfocal adhesionsoft X-ray contact microscopy

Identifiers

PMID34298899
PMCPMC8306697

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.