Evidence map›Paper›PMID 34298880›Full record

ArticleInternational journal of molecular sciences2021

Increased Endocytosis of Cadmium-Metallothionein through the 24p3 Receptor in an In Vivo Model with Reduced Proximal Tubular Activity.

Itzel Pamela Zavala-Guevara, Manolo Sibael Ortega-Romero, Juana Narváez-Morales, Tania Libertad Jacobo-Estrada, Wing-Kee Lee, Laura Arreola-Mendoza, Frank Thévenod, Olivier Christophe Barbier

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. The pathogenesis of albuminuria in cadmium nephropathy.Current research in toxicology · 2024
    Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. UsingPeerJ · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Itzel Pamela Zavala-GuevaraDepartamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Av. Instituto Politécnico Nacional 2508, Col. San Pedro Zacatenco, México CP 07360, Mexico.
Manolo Sibael Ortega-RomeroDepartamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Av. Instituto Politécnico Nacional 2508, Col. San Pedro Zacatenco, México CP 07360, Mexico.
Juana Narváez-MoralesDepartamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Av. Instituto Politécnico Nacional 2508, Col. San Pedro Zacatenco, México CP 07360, Mexico.
Tania Libertad Jacobo-EstradaDepartamento de Biociencias e Ingeniería, Centro Interdisciplinario de Investigaciones y Estudios Sobre Medio Ambiente y Desarrollo, Instituto Politécnico Nacional, 30 de Junio de 1520 s/n, Col. Barrio la Laguna Ticomán, México CP 07340, Mexico.ORCID 0000-0001-9682-8627
Wing-Kee LeeDepartment of Physiology, Pathophysiology and Toxicology and ZBAF (Center for Biomedical Education and Research), Faculty of Health-School of Medicine, Witten/Herdecke University, 58448 Witten, Germany.ORCID 0000-0002-7352-4679
Laura Arreola-MendozaDepartamento de Biociencias e Ingeniería, Centro Interdisciplinario de Investigaciones y Estudios Sobre Medio Ambiente y Desarrollo, Instituto Politécnico Nacional, 30 de Junio de 1520 s/n, Col. Barrio la Laguna Ticomán, México CP 07340, Mexico.
Frank ThévenodDepartment of Physiology, Pathophysiology and Toxicology and ZBAF (Center for Biomedical Education and Research), Faculty of Health-School of Medicine, Witten/Herdecke University, 58448 Witten, Germany.ORCID 0000-0001-8663-3498
Olivier Christophe BarbierDepartamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Av. Instituto Politécnico Nacional 2508, Col. San Pedro Zacatenco, México CP 07360, Mexico.ORCID 0000-0002-0378-3675
Instituto Politécnico Nacional · MXWitten/Herdecke University · DE

Funding

Bundesministerium für Bildung und Forschung 01DN16039Consejo Nacional de Ciencia y Tecnología 267755Consejo Nacional de Ciencia y Tecnología 426468
6 · The paper itself

Abstract

backgroundThe proximal tubule (PT) is the major target of cadmium (Cd

Indexed as

AnimalsCadmiumEndocytosisKidney Tubules, ProximalLow Density Lipoprotein Receptor-Related Protein-2MaleMetallothioneinMiceMice, Inbred C57BLNephronsReceptors, Cell SurfaceCadmiumcadmium-binding proteinLow Density Lipoprotein Receptor-Related Protein-2Lrp2 protein, mouseMetallothioneinReceptors, Cell SurfaceSlc22a17 protein, mousecadmium nephrotoxicitydistal tubulegentamicin-induced nephrotoxicitymetallothionein uptake

Identifiers

PMID34298880
PMCPMC8303618
OpenAlexW3179611785

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.