Evidence map›Paper›PMID 34298827›Full record

ArticleCancers2021

The Expression of Genes Related to Lipid Metabolism and Metabolic Disorders in Children before and after Hematopoietic Stem Cell Transplantation-A Prospective Observational Study.

Wojciech Czogała, Małgorzata Czogała, Kinga Kwiecińska, Mirosław Bik-Multanowski, Przemysław Tomasik, Przemysław Hałubiec, Agnieszka Łazarczyk, Karol Miklusiak, Szymon Skoczeń

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Wojciech CzogałaDepartment of Pediatric Oncology and Hematology, University Children's Hospital of Krakow, 30-663 Krakow, Poland.ORCID 0000-0002-9552-7889
Małgorzata CzogałaDepartment of Pediatric Oncology and Hematology, University Children's Hospital of Krakow, 30-663 Krakow, Poland.
Kinga KwiecińskaDepartment of Pediatric Oncology and Hematology, University Children's Hospital of Krakow, 30-663 Krakow, Poland.
Mirosław Bik-MultanowskiDepartment of Medical Genetics, Faculty of Medicine, Jagiellonian University Medical College, 30-663 Krakow, Poland.ORCID 0000-0003-1542-7050
Przemysław TomasikDepartment of Clinical Biochemistry, Faculty of Medicine, Jagiellonian University Medical College, 30-663 Krakow, Poland.ORCID 0000-0002-2061-999X
Przemysław HałubiecStudent Scientific Group of Pediatric Oncology and Hematology, Jagiellonian University Medical College, 30-663 Krakow, Poland.ORCID 0000-0002-7759-6039
Agnieszka ŁazarczykStudent Scientific Group of Pediatric Oncology and Hematology, Jagiellonian University Medical College, 30-663 Krakow, Poland.ORCID 0000-0002-3336-3321
Karol MiklusiakStudent Scientific Group of Pediatric Oncology and Hematology, Jagiellonian University Medical College, 30-663 Krakow, Poland.
Szymon SkoczeńDepartment of Pediatric Oncology and Hematology, University Children's Hospital of Krakow, 30-663 Krakow, Poland.ORCID 0000-0001-6867-2717
Jagiellonian University · PLUniwersytecki Szpital Dziecięcy · PL

Funding

Narodowe Centrum Nauki NN 407 198737
6 · The paper itself

Abstract

Metabolic disorders in children after hematopoietic stem cell transplantation (HSCT) are poorly characterized. However, it is known that dyslipidemia and insulin resistance are particularly common in these patients. We conducted a prospective study of 27 patients treated with HSCT to assess the possibility of predicting these abnormalities. We measured gene expressions using a microarray technique to identify differences in expression of genes associated with lipid metabolism before and after HSCT. In patients treated with HSCT, total cholesterol levels were significantly higher after the procedure compared with the values before HSCT. Microarray analysis revealed statistically significant differences in expressions of three genes,

Indexed as

childrendyslipidemiaexpressionHSCTinsulin resistancelipidsmicroarrays

Identifiers

PMID34298827
PMCPMC8306759
OpenAlexW3183266673

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.