Evidence map›Paper›PMID 34298803›Full record

ReviewCancers2021

Radiomics in the Setting of Neoadjuvant Radiotherapy: A New Approach for Tailored Treatment.

Valerio Nardone, Luca Boldrini, Roberta Grassi, Davide Franceschini, Ilaria Morelli, Carlotta Becherini, Mauro Loi, Daniela Greto, Isacco Desideri

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Delta radiomics: a systematic review.La Radiologia medica · 2021
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  17. Clinical Perspectives forMetabolites · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Valerio NardoneDepartment of Precision Medicine, University of Campania "L. Vanvitelli", 80138 Naples, Italy.ORCID 0000-0002-7347-0965
Luca BoldriniRadiation Oncology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.ORCID 0000-0002-5631-1575
Roberta GrassiDepartment of Precision Medicine, University of Campania "L. Vanvitelli", 80138 Naples, Italy.
Davide FranceschiniRadiotherapy and Radiosurgery Department, IRCCS Humanitas Research Hospital, via Manzoni 56, 20089 Milan, Italy.
Ilaria MorelliDepartment of Biomedical, Experimental and Clinical Sciences "Mario Serio", University of Florence, 50134 Florence, Italy.
Carlotta BecheriniDepartment of Biomedical, Experimental and Clinical Sciences "Mario Serio", University of Florence, 50134 Florence, Italy.
Mauro LoiRadiation Oncology Unit, Azienda Ospedaliero Universitaria Careggi, 50139 Florence, Italy.
Daniela GretoRadiation Oncology Unit, Azienda Ospedaliero Universitaria Careggi, 50139 Florence, Italy.
Isacco DesideriRadiation Oncology Unit, Azienda Ospedaliero Universitaria Careggi, 50139 Florence, Italy.
Azienda Ospedaliero-Universitaria Careggi · ITUniversity of Campania "Luigi Vanvitelli" · ITUniversity of Florence · ITAgostino Gemelli University Polyclinic · ITIRCCS Humanitas Research Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionNeoadjuvant radiotherapy is currently used mainly in locally advanced rectal cancer and sarcoma and in a subset of non-small cell lung cancer and esophageal cancer, whereas in other diseases it is under investigation. The evaluation of the efficacy of the induction strategy is made possible by performing imaging investigations before and after the neoadjuvant therapy and is usually challenging. In the last decade, texture analysis (TA) has been developed to help the radiologist to quantify and identify the parameters related to tumor heterogeneity, which cannot be appreciated by the naked eye. The aim of this narrative is to review the impact of TA on the prediction of response to neoadjuvant radiotherapy and or chemoradiotherapy. MATERIALS AND

methodsKey references were derived from a PubMed query. Hand searching and ClinicalTrials.gov were also used.

resultsThis paper contains a narrative report and a critical discussion of radiomics approaches in different fields of neoadjuvant radiotherapy, including esophageal cancer, lung cancer, sarcoma, and rectal cancer.

conclusionsRadiomics can shed a light on the setting of neoadjuvant therapies that can be used to tailor subsequent approaches or even to avoid surgery in the future. At the same, these results need to be validated in prospective and multicenter trials.

Indexed as

neoadjuvant radiotherapyradiomicstexture analysis

Identifiers

PMID34298803
PMCPMC8303203
OpenAlexW3187051145

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.