Evidence map›Paper›PMID 34298778›Full record

ArticleCancers2021

Collagenase-Expressing

Nancy D Ebelt, Vic Zamloot, Edith Zuniga, Kevin B Passi, Lukas J Sobocinski, Cari A Young, Bruce R Blazar, Edwin R Manuel

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
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  4. Microbial medicines: Unlocking the therapeutic potential of the microbiome in cancer treatment.Journal of controlled release : official journal of the Controlled Release Society · 2026
    Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Targeting collagen to optimize cancer immunotherapy.Experimental hematology & oncology · 2025
    Review
  10. Review
  11. Tumor-ColonizingBiomolecules · 2024
    Article
  12. Review
  13. Review
  14. Review
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  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Nancy D EbeltDepartment of Immuno-Oncology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.ORCID 0000-0002-1998-3719
Vic ZamlootDepartment of Immuno-Oncology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.
Edith ZunigaDepartment of Immuno-Oncology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.
Kevin B PassiDepartment of Immuno-Oncology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.
Lukas J SobocinskiDepartment of Immuno-Oncology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.
Cari A YoungDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Bruce R BlazarDepartment of Pediatrics, Division of Blood and Bone Marrow Transplantation, University of Minnesota Medical School, Minneapolis, MN 55455, USA.ORCID 0000-0002-9608-9841
Edwin R ManuelDepartment of Immuno-Oncology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.ORCID 0000-0002-4602-7060
City of Hope · USUniversity of Minnesota Medical Center · US

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI XIWEI WU · 1985 to 2026
$86.3M
Trial Design and Biostatistical Support CoreP01CA065493 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI J SUNIL RAO · 1995 to 2026
$48.2M
Beckman Research Institute, City of Hope Shared Resources GrantNCI NIH HHS P01 CA065493NCI NIH HHS P30 CA033572NCI NIH HHS P30CA033572
6 · The paper itself

Abstract

Therapeutic resistance in pancreatic ductal adenocarcinoma (PDAC) can be attributed, in part, to a dense extracellular matrix containing excessive collagen deposition. Here, we describe a novel

Indexed as

attenuated Salmonella typhimuriumcollagencollagenasedesmoplasiapancreatic ductal adenocarcinomatargeted therapiestherapeutic resistancetumor microenvironment

Identifiers

PMID34298778
PMCPMC8306875
OpenAlexW3184603480

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.