Evidence map›Paper›PMID 34298751›Full record

ArticleCancers2021

Neurocognitive Outcomes in Pediatric Patients Following Brain Irradiation.

Katharina Weusthof, Peggy Lüttich, Sebastian Regnery, Laila König, Denise Bernhardt, Olaf Witt, Klaus Herfarth, Andreas Unterberg, Christine Jungk, Benjamin Farnia and 5 more

Abstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Article
  6. Article
  7. Article
  8. Neuropsychological outcome in pediatric brain tumor survivors treated with proton radiation prior to age 4 years.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Long-term neurocognitive function after whole-brain radiotherapy in patients with melanoma brain metastases in the era of immunotherapy.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2022
    Article
  19. Review
  20. ExtracranialFrontiers in neuroscience · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Katharina WeusthofDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Peggy LüttichSection of Pediatric Brain Tumors, Department of Pediatric Oncology, Hematology and Immunology, University Medical Center for Children and Adolescents, 69120 Heidelberg, Germany.
Sebastian RegneryDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Laila KönigDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Denise BernhardtDepartment of Radiation Oncology, Technische Universität München, 81675 München, Germany.ORCID 0000-0001-5231-9097
Olaf WittSection of Pediatric Brain Tumors, Department of Pediatric Oncology, Hematology and Immunology, University Medical Center for Children and Adolescents, 69120 Heidelberg, Germany.
Klaus HerfarthDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Andreas UnterbergDepartment of Neurosurgery, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Christine JungkDepartment of Neurosurgery, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Benjamin FarniaDepartment of Radiation Oncology, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33136, USA.
Stephanie E CombsDepartment of Radiation Oncology, Technische Universität München, 81675 München, Germany.
Jürgen DebusDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Stefan RiekenDepartment of Radiation Oncology, University Hospital Goettingen, 37075 Goettingen, Germany.
Semi HarrabiDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany.ORCID 0000-0003-1195-7150
Sebastian AdebergDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany.ORCID 0000-0001-8463-514X

Funding

Dietmar Hopp Stiftung D10051609
6 · The paper itself

Abstract

Advanced radiation techniques can reduce the severity of neurocognitive sequelae in young brain tumor patients. In the present analysis, we sought to compare neurocognitive outcomes after proton irradiation with patients who underwent photon radiotherapy (RT) and surgery. Neurocognitive outcomes were evaluated in 103 pediatric brain tumor patients (proton RT

Indexed as

neurocognitive functionneuropsychological assessmentpediatric brain tumorphoton irradiationproton irradiationtreatment modality comparison

Identifiers

PMID34298751
PMCPMC8307409

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.