Evidence map›Paper›PMID 34298725›Full record

ArticleCancers2021

Early Imaging and Molecular Changes with Neoadjuvant Bevacizumab in Stage II/III Breast Cancer.

José Manuel López-Vega, Isabel Álvarez, Antonio Antón, José Juan Illarramendi, Antonio Llombart, Valentina Boni, María José García-Velloso, Josep María Martí-Climent, Luis Pina, Jesús García-Foncillas

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 1 country.

José Manuel López-VegaDepartment of Medical Oncology, Marqués de Valdecilla University Hospital, 39008 Santander, Spain.
Isabel ÁlvarezDepartment of Medical Oncology, University Hospital Donostia, 20080 Donostia-San Sebastián, Spain.ORCID 0000-0001-8958-0694
Antonio AntónDepartment of Medical Oncology, University Hospital Miguel Servet, 50009 Zaragoza, Spain.ORCID 0000-0002-2802-6232
José Juan IllarramendiMedical Oncology Department, Complejo Hospitalario de Navarra, 31008 Pamplona, Spain.
Antonio LlombartDepartment of Medical Oncology, Hospital Arnau de Vilanova, 46015 Lleida, Spain.
Valentina BoniSTART Madrid CIOCC, Hospital Universitario HM Sanchinarro, 28050 Madrid, Spain.
María José García-VellosoNuclear Medicine Department, Clínica Universidad de Navarra, 31008 Pamplona, Spain.ORCID 0000-0002-0829-2808
Josep María Martí-ClimentDepartment of Medical Physics and Radiation Safety, Clínica Universidad de Navarra, 31008 Pamplona, Spain.
Luis PinaDepartment of Radiology, Clínica Universidad de Navarra, 31008 Pamplona, Spain.
Jesús García-FoncillasTranslational Oncology Division, OncoHealth Institute, University Hospital "Fundación Jiménez Díaz", Autonomous University of Madrid, 28040 Madrid, Spain.ORCID 0000-0002-7591-8006
Clinica Universidad de Navarra · ESBiogipuzkoa Health Research Institute · ESComplejo Hospitalario de Navarra · ESHospital Arnau de Vilanova · ESHospital Universitario Fundación Jiménez Díaz · ESHospital Universitario HM Sanchinarro · ESHospital Universitario Miguel Servet · ESMarqués de Valdecilla University Hospital · ES

Funding

F. Hoffman-La Roche Ltd; Roche Spain. not availableRoche Spain not available
6 · The paper itself

Abstract

This prospective, phase II study evaluated novel biomarkers as predictors of response to bevacizumab in patients with breast cancer (BC), using serial imaging methods and gene expression analysis. Patients with primary stage II/III BC received bevacizumab 15 mg/kg (cycle 1; C1), then four cycles of neoadjuvant docetaxel doxorubicin, and bevacizumab every 3 weeks (C2-C5). Tumour proliferation and hypoxic status were evaluated using

Indexed as

bevacizumabbreast cancer biomarkersdynamic contrast-enhanced magnetic resonance imagingpositron emission tomographyvascular endothelial growth factor receptor-2

Identifiers

PMID34298725
PMCPMC8307791
OpenAlexW3180965246

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.