Evidence map›Paper›PMID 34298701›Full record

ReviewCancers2021

Current Status and Future Perspectives about Molecular Biomarkers of Nasopharyngeal Carcinoma.

Pui Yan Siak, Alan Soo-Beng Khoo, Chee Onn Leong, Boon-Peng Hoh, Shiau-Chuen Cheah

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
  2. Review
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  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Observational
  13. Biological biomarkers of oral cancer.Periodontology 2000 · 2024
    Review
  14. Article
  15. Circulating tumor cells: a valuable indicator for locally advanced nasopharyngeal carcinoma.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Article
  16. Review
  17. Review
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Pui Yan SiakFaculty of Medicine and Health Sciences, UCSI University, Kuala Lumpur 56000, Malaysia.
Alan Soo-Beng KhooCancer Research Centre, Molecular Pathology Unit, Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia, Shah Alam 40170, Selangor, Malaysia.ORCID 0000-0002-8268-5271
Chee Onn LeongInstitute for Research, Development and Innovation, International Medical University, Kuala Lumpur 57000, Malaysia.ORCID 0000-0002-6353-9703
Boon-Peng HohFaculty of Medicine and Health Sciences, UCSI University, Kuala Lumpur 56000, Malaysia.
Shiau-Chuen CheahFaculty of Medicine and Health Sciences, UCSI University, Kuala Lumpur 56000, Malaysia.ORCID 0000-0002-9247-7265
UCSI University · MYIMU University · MYMinistry of Health · MY

Funding

Ministry of Higher Education FRGS/1/2020/SKK0/UCSI/02/2UCSI University REIG-FMS-2020/009
6 · The paper itself

Abstract

Nasopharyngeal carcinoma (NPC) is an epithelial malignancy that shows a remarkable ethnic and geographical distribution. It is one of the major public health problems in some countries, especially Southern China and Southeast Asia, but rare in most Western countries. Multifactorial interactions such as Epstein-Barr virus infection, individual's genetic susceptibility, as well as environmental and dietary factors may facilitate the pathogenesis of this malignancy. Late presentation and the complex nature of the disease have led it to become a major cause of mortality. Therefore, an effective, sensitive, and specific molecular biomarker is urgently needed for early disease diagnosis, prognosis, and prediction of metastasis and recurrence after treatment. In this review, we discuss the recent research status of potential biomarker discovery and the problems that need to be explored further for better NPC management. By studying the aberrant pattern of these candidate biomarkers that promote NPC development and progression, we are able to understand the complexity of this malignancy better, hence positing our stands better towards strategies that may provide a way forward to the discovery of more reliable and specific biomarkers for diagnosis and targeted therapeutic development.

Indexed as

biomarkersepigeneticsEpstein–Barr virusnasopharyngeal carcinoma (NPC)therapeutic resistance

Identifiers

PMID34298701
PMCPMC8305767
OpenAlexW3180598434

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.