Evidence map›Paper›PMID 34298669›Full record

ArticleCancers2021

Characteristics and Survival Outcomes of Hepatocellular Carcinoma Developed after HCV SVR.

Ming-Lun Yeh, Po-Cheng Liang, Pei-Chien Tsai, Shu-Chi Wang, Jennifer Leong, Eiichi Ogawa, Dae Won Jun, Cheng-Hao Tseng, Charles Landis, Yasuhito Tanaka and 8 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 9 institutions in 4 countries.

Ming-Lun YehDepartment of Internal Medicine and Hepatitis Center, Hepatobiliary Division, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
Po-Cheng LiangDepartment of Internal Medicine and Hepatitis Center, Hepatobiliary Division, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
Pei-Chien TsaiDepartment of Internal Medicine and Hepatitis Center, Hepatobiliary Division, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
Shu-Chi WangDepartment of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung 807, Taiwan.ORCID 0000-0001-9691-7507
Jennifer LeongHenry D. Janowitz Division of Gastroenterology, Mt. Sinai Health System, New York, NY 10029, USA.
Eiichi OgawaDepartment of General Internal Medicine, Kyushu University Hospital, Fukuoka 812-8582, Japan.ORCID 0000-0002-5082-3967
Dae Won JunDepartment of Gastroenterology, School of Medicine, Hanyang University, Seoul 04763, Korea.ORCID 0000-0002-2875-6139
Cheng-Hao TsengDivision of Gastroenterology of Hepatology, E-Da Hospital, I-Shou University, Kaohsiung 82445, Taiwan.
Charles LandisDepartment of Gastroenterology, University of Washington Medical Center, Seattle, WA 98195, USA.
Yasuhito TanakaDepartment of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8555, Japan.
Chung-Feng HuangDepartment of Internal Medicine and Hepatitis Center, Hepatobiliary Division, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
Jun HayashiKyushu General Internal Medicine Center, Haradoi Hospital, Fukuoka 812-0063, Japan.
Yao-Chun HsuDivision of Gastroenterology of Hepatology, E-Da Hospital, I-Shou University, Kaohsiung 82445, Taiwan.
Jee-Fu HuangDepartment of Internal Medicine and Hepatitis Center, Hepatobiliary Division, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.ORCID 0000-0002-2752-7051
Chia-Yen DaiDepartment of Internal Medicine and Hepatitis Center, Hepatobiliary Division, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
Wan-Long ChuangDepartment of Internal Medicine and Hepatitis Center, Hepatobiliary Division, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.ORCID 0000-0002-2376-421X
Mindie H NguyenDivision of Gastroenterology and Hepatology, Department of Medicine, Stanford University Medical Center, Palo Alto, CA 94304, USA.
Ming-Lung YuDepartment of Internal Medicine and Hepatitis Center, Hepatobiliary Division, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.ORCID 0000-0001-8145-1900
Kaohsiung Medical University · TWE-Da Hospital · TWHanyang University · KRHaradoi Hospital · JPKumamoto University · JPKyushu University Hospital · JPSinai Health System · USStanford Medicine · USUniversity of Washington Medical Center · US

Funding

Japan Agency for Medical Research and Development JP19fk0210048, JP20fk0210048Kaohsiung Medical University KMU-TC108A04-3, KMU-TC108B06, KMU-TC108B07, KMU-TC109B05, KMU-DK107004, KMU-DK109002, 105KMUOR08, and MOST 108-2314-B-037 -066 -MY3Kaohsiung Medical University Chung-Ho Memorial Hospital KMUH-DK109005~1, KMUH-DK109002, KMUH106-6R09, and KMUH108-8R08
6 · The paper itself

Abstract

The clinical presentation and survival of hepatocellular carcinoma (HCC) after hepatitis C virus (HCV) eradication as compared to HCC in viremic patients are not well characterized. We aimed to investigate the characteristics and survival between HCV patients with and without viremia at HCC diagnosis.: We retrospectively analyzed overall survival outcomes in 1389 HCV-related HCC patients, including 301 with HCC developed after HCV eradication (post-SVR HCC) and 1088 with HCV viremia at HCC diagnosis (viremic HCC). We also evaluated overall survival in the two groups using propensity score-matching methods.: At HCC diagnosis, post-SVR HCC patients were older, less obese, less likely cirrhotic, with better liver function, lower alfa-fetoprotein levels, earlier BCLC stages, and higher rate of treatment with surgery. Overall, post-SVR HCC patients had higher median survival than viremic patients (153.3 vs. 55.6 months,

Indexed as

chronic hepatitis Chepatitis C virushepatocellular carcinomasurvivalviremia

Identifiers

PMID34298669
PMCPMC8306695
OpenAlexW3179827400

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.