Evidence map›Paper›PMID 34298604›Full record

ReviewCancers2021

Polyester Polymeric Nanoparticles as Platforms in the Development of Novel Nanomedicines for Cancer Treatment.

Enrique Niza, Alberto Ocaña, José Antonio Castro-Osma, Iván Bravo, Carlos Alonso-Moreno

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 52 citations in OpenAlex.

  1. Review
  2. Article
  3. Nano-Based Technology in Glioblastoma.Molecules (Basel, Switzerland) · 2025
    Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Innovative nanoparticle strategies for treating oral cancers.Medical oncology (Northwood, London, England) · 2025
    Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Engineered biomimetic micro/nano-materials for tissue regeneration.Frontiers in bioengineering and biotechnology · 2023
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Enrique NizaCentro Regional de Investigaciones Biomédicas, Unidad NanoCRIB, 02008 Albacete, Spain.ORCID 0000-0003-2845-4509
Alberto OcañaExperimental Therapeutics Unit, Hospital Clínico San Carlos, IdISSC and CIBERONC, 28040 Madrid, Spain.
José Antonio Castro-OsmaCentro Regional de Investigaciones Biomédicas, Unidad NanoCRIB, 02008 Albacete, Spain.ORCID 0000-0002-5029-0507
Iván BravoCentro Regional de Investigaciones Biomédicas, Unidad NanoCRIB, 02008 Albacete, Spain.ORCID 0000-0003-1589-5399
Carlos Alonso-MorenoCentro Regional de Investigaciones Biomédicas, Unidad NanoCRIB, 02008 Albacete, Spain.ORCID 0000-0002-7588-0781
University of Castilla-La Mancha · ESHospital Clínico San Carlos · ES

Funding

institudo de salud carlos III PI16/01121Ministerio de Ciencia e Innovación CTQ2016-81797-REDCMinisterio de Ciencia e Innovación CTQ2017-84131-R
6 · The paper itself

Abstract

Many therapeutic agents have failed in their clinical development, due to the toxic effects associated with non-transformed tissues. In this context, nanotechnology has been exploited to overcome such limitations, and also improve navigation across biological barriers. Amongst the many materials used in nanomedicine, with promising properties as therapeutic carriers, the following one stands out: biodegradable and biocompatible polymers. Polymeric nanoparticles are ideal candidates for drug delivery, given the versatility of raw materials and their feasibility in large-scale production. Furthermore, polymeric nanoparticles show great potential for easy surface modifications to optimize pharmacokinetics, including the half-life in circulation and targeted tissue delivery. Herein, we provide an overview of the current applications of polymeric nanoparticles as platforms in the development of novel nanomedicines for cancer treatment. In particular, we will focus on the raw materials that are widely used for polymeric nanoparticle generation, current methods for formulation, mechanism of action, and clinical investigations.

Indexed as

cancer treatmentdrug delivery systemnanomedicinepolymeric nanoparticles

Identifiers

PMID34298604
PMCPMC8304499
OpenAlexW3182955193

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.