ArticleJournal of the American Geriatrics Society2021
Serum albumin and risks of hospitalization and death: Findings from the Atherosclerosis Risk in Communities study.
Article in Journal of the American Geriatrics Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of Physical Exercise with and Without Nutritional Supplementation on Serum Albumin in Older People: A Systematic Review and Meta-Analysis.Biomolecules · 2026Pooled it
- Intact Parathyroid Hormone Reference Intervals: Importance of Pre-Processing for Indirect Reference Interval Estimation.Diagnostics (Basel, Switzerland) · 2026Article
- Association between serum albumin to creatinine ratio and mortality risk in patients with acute-on-chronic liver failure.Scientific reports · 2025Article
- Factor XIII and cardiovascular disease: biomarker, culprit or victim in acute myocardial infarction outcomes?International journal of cardiology. Heart & vasculature · 2025Article
- Serum Sodium, Potassium, Magnesium, Calcium, and Phosphorus Levels and Risk of Fracture in the Community.The Journal of clinical endocrinology and metabolism · 2025Article
- Article
- Association of alkaline-phosphatase/albumin ratio with all-cause mortality in critically ill patients with ischemic stroke: a retrospective study.Frontiers in neurology · 2025Article
- Association between the age-to-serum albumin ratio and all-cause mortality in patients with acute myocardial infarction: a retrospective cohort study.Frontiers in cardiovascular medicine · 2025Article
- Article
- Independent and combined associations of high-density lipoprotein cholesterol-modified triglyceride-glucose index with all-cause and cardiovascular mortality in patients with acute decompensated heart failure.Frontiers in endocrinology · 2025Article
- The association between hypoalbuminemia and risk of death due to cancer and vascular disease in individuals aged 65 years and older: findings from the prospective Moli-sani cohort study.EClinicalMedicine · 2024Article
- Article
- Synergistic impact of plasma albumin and cognitive function on all-cause mortality in Chinese older adults: a prospective cohort study.Frontiers in nutrition · 2024Article
- Association between serum creatinine to albumin ratio and short- and long-term all-cause mortality in patients with acute pancreatitis admitted to the intensive care unit: a retrospective analysis based on the MIMIC-IV database.Frontiers in immunology · 2024Article
- Relationship between dietary protein, serum albumin, and mortality in asthmatic populations: a cohort study.Frontiers in immunology · 2024Article
- Proof-of-concept for an automatable mortality prediction scoring in hospitalised older adults.Frontiers in medicine · 2024Article
- Multiple cardiometabolic diseases enhance the adverse effects of hypoalbuminemia on mortality among centenarians in China: a cohort study.Diabetology & metabolic syndrome · 2023Article
- Factors Associated with Low Albumin in Community-Dwelling Older Adults Aged 75 Years and Above.International journal of environmental research and public health · 2023Article
- Development and validation of a score predicting mortality for older patients with mitral regurgitation.Journal of geriatric cardiology : JGC · 2023Article
- Association of albumin levels with the risk of intracranial atherosclerosis.BMC neurology · 2023Article
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Abstract
objectivesTo determine whether lower serum albumin in community-dwelling, older adults is associated with increased risk of hospitalization and death independent of pre-existing disease.
designProspective cohort study of participants in the fifth visit of the Atherosclerosis Risk in Communities (ARIC) study. Baseline data were collected from 2011 to 2013. Follow-up was available to December 31, 2017. Replication was performed in Geisinger, a health system in rural Pennsylvania.
settingFor ARIC, four US communities: Washington County, Maryland; Forsyth County, North Carolina; Jackson, Mississippi; and suburbs of Minneapolis, Minnesota.
participantsA total of 4947 community-dwelling men and women aged 66 to 90 years. EXPOSURE: Serum albumin. MAIN OUTCOMES: Incident all-cause hospitalization and death.
resultsAmong the 4947 participants, mean age was 75.5 years (SD: 5.12) and mean baseline serum albumin concentration was 4.05 g/dL (SD: 0.30). Over a median follow-up period of 4.42 years (interquartile interval: 4.16-5.05), 553 participants (11.2%) died and 2457 participants (49.7%) were hospitalized at least once. The total number of hospitalizations was 5725. In analyses adjusted for demographics and numerous clinical characteristics, including tobacco use, obesity, frailty, cardiovascular disease, kidney disease, diabetes C-reactive protein (CRP), cognitive status, alcohol use, medication use, respiratory disease, and systolic blood pressure, 1 g/dL lower baseline serum albumin concentration was associated with higher risk of both hospitalization (incidence rate ratio [IRR]: 1.58; 95% confidence interval [CI]: 1.36-1.82; p < 0.001) and death (hazard ratio [HR]: 1.67; 95% CI: 1.24-2.24; p < 0.001). Associations were weaker with older age but not different by frailty status or level of high-sensitivity CRP. Associations between serum albumin, hospitalizations, and death were also similar in a real-world cohort of primary care patients.
conclusionsLower baseline serum albumin was significantly associated with increased risk of both all-cause hospitalization and death, independent of pre-existing disease. Older adults with low serum albumin should be considered a high-risk population and targeted for interventions to reduce the risk of adverse outcomes.
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