ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2021
A reexamination of motor and prefrontal TMS in tobacco use disorder: Time for personalized dosing based on electric field modeling?
Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Mapping symptom-general and symptom-specific targets for transcranial magnetic stimulation in schizophrenia: an electric-field modeling meta-analysis.Molecular psychiatry · 2026Pooled it
- Outcome measures for electric field modeling in tES and TMS: A systematic review and large-scale modeling study.NeuroImage · 2023Pooled it
- DLPFC rTMS is more effective than sham or orbitofrontal stimulation for smoking cessation and alters frontal brain activity: A double-blind, sham-controlled randomized clinical trial.Journal of psychiatric research · 2026Trial
- Lack of effects of eight-week left dorsolateral prefrontal theta burst stimulation on white matter macro/microstructure and connection in autism.Brain imaging and behavior · 2024Trial
- How Standardized Is Transcranial Magnetic Stimulation Treatment for Depression? Large-Cohort Modeling Reveals Systematic Dosimetric Variability.Psychotherapy and psychosomatics · 2026Article
- Investigating the effects of TMS-related somatosensory inputs on TMS-evoked potentials provides evidence against significant interaction.Scientific reports · 2026Article
- Sources of the N15 TMS-evoked potential following motor cortex stimulation localize rostrals to TMS-induced electric fields and depend on dose.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Single-day accelerated TMS with D-cycloserine augmentation for depression: A placebo-controlled trial.Research square · 2025Article
- Enhanced Bilateral Accelerated Theta Burst Stimulation for Comorbid Anxiety and Depressive Disorders: The Seville Protocol.Alpha psychiatry · 2025Article
- Differences in scalp-to-cortex tissues across age groups, sexes and brain regions: Implications for neuroimaging and brain stimulation techniques.Neurobiology of aging · 2024Article
- Addiction-related brain networks identification via Graph Diffusion Reconstruction Network.Brain informatics · 2024Article
- Electric-field-based dosing for TMS.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Electric field distribution predicts efficacy of accelerated intermittent theta burst stimulation for late-life depression.Frontiers in psychiatry · 2023Article
- Optimized APPS-tDCS electrode position, size, and distance doubles the on-target stimulation magnitude in 3000 electric field models.Scientific reports · 2022Article
- TAP: targeting and analysis pipeline for optimization and verification of coil placement in transcranial magnetic stimulation.Journal of neural engineering · 2022Article
- The Problem and Potential of TMS' Infinite Parameter Space: A Targeted Review and Road Map Forward.Frontiers in psychiatry · 2022Review
- Dosing Transcranial Magnetic Stimulation of the Primary Motor and Dorsolateral Prefrontal Cortices With Multi-Scale Modeling.Frontiers in neuroscience · 2022Article
- Neuronavigation maximizes accuracy and precision in TMS positioning: Evidence from 11,230 distance, angle, and electric field modeling measurements.Brain stimulationArticle
- Article
- Four electric field modeling methods of Dosing Prefrontal Transcranial Magnetic Stimulation (TMS): Introducing APEX MT dosimetry.Brain stimulationArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectiveIn this study, we reexamined the use of 120% resting motor threshold (rMT) dosing for transcranial magnetic stimulation (TMS) over the left dorsolateral prefrontal cortex (DLPFC) using electric field modeling.
methodsWe computed electric field models in 38 tobacco use disorder (TUD) participants to compare figure-8 coil induced electric fields at 100% rMT over the primary motor cortex (M1), and 100% and 120% rMT over the DLPFC. We then calculated the percentage of rMT needed for motor-equivalent induced electric fields at the DLPFC and modeled this intensity for each person.
resultsElectric fields from 100% rMT stimulation over M1 were significantly larger than what was modeled in the DLPFC using 100% rMT (p < 0.001) and 120% rMT stimulation (p = 0.013). On average, TMS would need to be delivered at 133.5% rMT (range = 79.9 to 247.5%) to produce motor-equivalent induced electric fields at the DLPFC of 158.2 V/m.
conclusionsTMS would have to be applied at an average of 133.5% rMT over the left DLPFC to produce equivalent electric fields to 100% rMT stimulation over M1 in these 38 TUD patients. The high interindividual variability between motor and prefrontal electric fields for each participant supports using personalized electric field modeling for TMS dosing to ensure that each participant is not under- or over-stimulated. SIGNIFICANCE: These electric field modeling in TUD data suggest that 120% rMT stimulation over the DLPFC delivers sub-motor equivalent electric fields in many individuals (73.7%). With further validation, electric field modeling may be an impactful method of individually dosing TMS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.