Evidence map›Paper›PMID 34298375›Full record

Observational studyEuropean journal of cancer (Oxford, England : 1990)2021

Coronavirus disease 2019 in patients with neuroendocrine neoplasms: Preliminary results of the INTENSIVE study.

Nicola Fazio, Lorenzo Gervaso, Thorvardur R Halfdanarson, Anna La Salvia, Johannes Hofland, Jorge Hernando, Mohamad B Sonbol, Rocio Garcia-Carbonero, Jaume Capdevila, Wouter W de Herder and 11 more

Erratum issuedOpen access · bronzeAbstract readMulticenter StudyObservational Study
In one paragraph

Observational study in European journal of cancer (Oxford, England : 1990), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors at 11 institutions in 5 countries.

Nicola FazioDivision of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology (IEO) IRCCS, Milan, Italy. Electronic address: nicola.fazio@ieo.it.
Lorenzo GervasoDivision of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology (IEO) IRCCS, Milan, Italy; Molecular Medicine Program, University of Pavia, Pavia, Italy.
Thorvardur R HalfdanarsonDivision of Medical Oncology Mayo Clinic, Rochester, MN, USA.
Anna La SalviaMedical Oncology Department, Hospital Universitario Doce de Octubre, Imas12, UCM, Madrid, Spain.
Johannes HoflandDepartment of Internal Medicine, Sector Endocrinology, Rotterdam, the Netherlands.
Jorge HernandoVall Hebron University Hospital and Vall Hebron Institute of Oncology (VHIO), Barcelona, Spain.
Mohamad B SonbolDepartment of Hematology and Oncology Mayo Clinic, Phoenix, AZ, USA.
Rocio Garcia-CarboneroMedical Oncology Department, Hospital Universitario Doce de Octubre, Imas12, UCM, Madrid, Spain.
Jaume CapdevilaVall Hebron University Hospital and Vall Hebron Institute of Oncology (VHIO), Barcelona, Spain.
Wouter W de HerderDepartment of Internal Medicine, Sector Endocrinology, Rotterdam, the Netherlands.
Anna KoumarianouHematology-Oncology Unit, Fourth Department of Internal Medicine, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Gregory Kaltsas1st Department of Propaedeutic Internal Medicine, Endocrine Unit, National and Kapodistrian, University of Athens, 11527 Athens, Greece.
Maura RossiOncology Unit and Centro Documentazione Osteonecrosi, Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
Simona Grozinsky-GlasbergNeuroendocrine Tumors Unit, ENETS Center of Excellence, Department of Endocrinology and Metabolism Service, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Kira OleinikovNeuroendocrine Tumors Unit, ENETS Center of Excellence, Department of Endocrinology and Metabolism Service, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Sabrina BoselliData Management-Clinical Trial Office. Scientific Direction. European Institute of Oncology (IEO) IRCCS, Milan, Italy.
Darina TamayoData Management-Clinical Trial Office. Scientific Direction. European Institute of Oncology (IEO) IRCCS, Milan, Italy.
Vincenzo BagnardiDepartment of Statistics and Quantitative Methods, University of Milan-Bicocca, Milan, Italy.
Alice LaffiDivision of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology (IEO) IRCCS, Milan, Italy.
Manila RubinoDivision of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology (IEO) IRCCS, Milan, Italy.
Francesca SpadaDivision of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology (IEO) IRCCS, Milan, Italy.
European Institute of Oncology · ITHadassah Medical Center · ILHospital Universitario 12 De Octubre · ESIstituti di Ricovero e Cura a Carattere Scientifico · ITNational and Kapodistrian University of Athens · GRVall d'Hebron Hospital Universitari · ESAzienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo · ITMayo Clinic in Arizona · USUniversity of Milano-Bicocca · ITUniversity of Pavia · ITWinnMed · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSpecific data regarding coronavirus disease 2019 (COVID-19) in patients with neuroendocrine neoplasms (NENs) are lacking. The aim of this study is to describe the characteristics of patients with NENs who tested severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive. MATERIAL AND

methodsThis is a worldwide study collecting cases of patients with NENs along with a positive nasopharyngeal swab reverse transcriptase-polymerase chain reaction (RT-PCR) test for SARS-CoV-2 between June 1, 2020, and March 31, 2021. Centres treating patients with NENs were directly contacted by the principal investigator. Patients with NENs of any primary site, grade and stage were included, excluding small-cell lung carcinoma and mixed adenoneuroendocrine carcinoma.

resultsAmong 81 centres directly contacted, 88.8% responded and 48.6% of them declined due to lack of cases or interest. On March 31

conclusionsPatients included in this study reflect the typical NEN population regardless of SARS-CoV-2. In most cases, they overcome COVID-19 without need of intensive care, short-term sequelae and discontinuation of systemic oncological therapy.

Indexed as

Global HealthAdultAgedCarcinoma, NeuroendocrineComorbidityCOVID-19FemaleHumansMaleMiddle AgedPreliminary DataProspective StudiesRetrospective StudiesRisk FactorsTime FactorsTreatment OutcomeCoronavirusCOVID-19Neuroendocrine neoplasmsNeuroendocrine tumoursSARS-CoV-2

Identifiers

PMID34298375
PMCPMC8241688
OpenAlexW3176913781

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.