Evidence map›Paper›PMID 34298132›Full record

ArticleBioorganic & medicinal chemistry letters2021

Structural and biophysical characterization of the Burkholderia pseudomallei IspF inhibitor L-tryptophan hydroxamate.

Joy M Blain, Dakota L Grote, Sydney M Watkins, Gashaw M Goshu, Chanté Muller, James L Gorman, Gina Ranieri, Richard L Walter, Heike Hofstetter, James R Horn and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Joy M BlainDepartment of Chemistry and Biochemistry, Northern Illinois University, 1425 W. Lincoln Hwy., DeKalb, IL 60115, USA.
Dakota L GroteDepartment of Chemistry and Biochemistry, Northern Illinois University, 1425 W. Lincoln Hwy., DeKalb, IL 60115, USA.
Sydney M WatkinsDepartment of Chemistry and Biochemistry, Northern Illinois University, 1425 W. Lincoln Hwy., DeKalb, IL 60115, USA.
Gashaw M GoshuDepartment of Chemistry and Biochemistry, Northern Illinois University, 1425 W. Lincoln Hwy., DeKalb, IL 60115, USA.
Chanté MullerDepartment of Chemistry and Biochemistry, Northern Illinois University, 1425 W. Lincoln Hwy., DeKalb, IL 60115, USA.
James L GormanDepartment of Chemistry and Biochemistry, Northern Illinois University, 1425 W. Lincoln Hwy., DeKalb, IL 60115, USA.
Gina RanieriShamrock Structures LLC, 1440 Davey Rd, Woodridge, IL 60208, USA.
Richard L WalterShamrock Structures LLC, 1440 Davey Rd, Woodridge, IL 60208, USA.
Heike HofstetterDepartment of Chemistry, Univeristy of Wisconsin Madison, WI 53706, USA.
James R HornDepartment of Chemistry and Biochemistry, Northern Illinois University, 1425 W. Lincoln Hwy., DeKalb, IL 60115, USA. Electronic address: jrhorn@niu.edu.
Timothy J HagenDepartment of Chemistry and Biochemistry, Northern Illinois University, 1425 W. Lincoln Hwy., DeKalb, IL 60115, USA. Electronic address: thagen@niu.edu.
Northern Illinois University · US

Funding

Laser-Enhanced NMR Instrumentation for Chemical and Biochemical ResearchS10OD012245 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI CAVAGNERO, SILVIA · 2013 to 2013
$1.0M
Design and Study of IspF Inhibitors as Antibacterial AgentsR15AI113653 · NIAID · NORTHERN ILLINOIS UNIVERSITY · PI HAGEN, TIMOTHY JOSEPH · 2014 to 2014
$356k
NIAID NIH HHS HHSN272201700059CNIAID NIH HHS R15 AI113653NIH HHS S10 OD012245
6 · The paper itself

Abstract

The enzyme 2-methylerythritol 2,4-cyclodiphosphate synthase, IspF, is essential for the biosynthesis of isoprenoids in most bacteria, some eukaryotic parasites, and the plastids of plant cells. The development of inhibitors that target IspF may lead to novel classes of anti-infective agents or herbicides. Enantiomers of tryptophan hydroxamate were synthesized and evaluated for binding to Burkholderia pseudomallei (Bp) IspF. The L-isomer possessed the highest potency, binding BpIspF with a K

Indexed as

Bacterial ProteinsBinding SitesBurkholderia pseudomalleiDose-Response Relationship, DrugEnzyme InhibitorsModels, MolecularMolecular StructureStructure-Activity RelationshipTryptophanBacterial ProteinsEnzyme InhibitorsTryptophantryptophanhydroxamateBinding thermodynamicsBurkholderia pseudomalleiIsothermal titration calorimetryIspFMEP pathwayX-ray Crystallography

Identifiers

PMID34298132
PMCPMC8407143
OpenAlexW3183886139

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.