Evidence map›Paper›PMID 34298086›Full record

ArticleRegulatory toxicology and pharmacology : RTP2021

Performance of the GHS Mixtures Equation for Predicting Acute Oral Toxicity.

Jon Hamm, David Allen, Patricia Ceger, Tara Flint, Anna Lowit, Lindsay O'Dell, Jenny Tao, Nicole Kleinstreuer

Abstract read
In one paragraph

Article in Regulatory toxicology and pharmacology : RTP, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jon HammILS, P.O. Box 13501, Research Triangle Park, NC, 27709, USA. Electronic address: jhamm@ils-inc.com.
David AllenILS, P.O. Box 13501, Research Triangle Park, NC, 27709, USA. Electronic address: dallen@ils-inc.com.
Patricia CegerILS, P.O. Box 13501, Research Triangle Park, NC, 27709, USA. Electronic address: pceger1@ils-inc.com.
Tara FlintOffice of Pesticide Programs, U.S. Environmental Protection Agency, 1200 Pennsylvania Ave, NW, Washington, DC, 20460, USA. Electronic address: Flint.Tara@epa.gov.
Anna LowitOffice of Pesticide Programs, U.S. Environmental Protection Agency, 1200 Pennsylvania Ave, NW, Washington, DC, 20460, USA. Electronic address: Lowit.Anna@epa.gov.
Lindsay O'DellOffice of Pesticide Programs, U.S. Environmental Protection Agency, 1200 Pennsylvania Ave, NW, Washington, DC, 20460, USA. Electronic address: Odell.Lindsay@epa.gov.
Jenny TaoOffice of Pesticide Programs, U.S. Environmental Protection Agency, 1200 Pennsylvania Ave, NW, Washington, DC, 20460, USA. Electronic address: Tao.Jenny@epa.gov.
Nicole KleinstreuerNational Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC, 27709, USA. Electronic address: nicole.kleinstreuer@nih.gov.

Funding

NIEHS NIH HHS HHSN273201500010C
6 · The paper itself

Abstract

Acute oral toxicity classifications are based on the estimated chemical dose causing lethality in 50 % of laboratory animals tested (LD

Indexed as

AgrochemicalsComplex MixturesDetergentsDose-Response Relationship, DrugHazardous SubstancesLethal Dose 50Mouth DiseasesPesticidesToxicity Tests, AcuteUnited NationsAgrochemicalsComplex MixturesDetergentsHazardous SubstancesPesticidesAcute systemic toxicityAlternative approachesGHS Mixtures equationNon-animal methodsRegulatory requirements

Identifiers

PMID34298086
PMCPMC9623877

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.