Evidence map›Paper›PMID 34298007›Full record

Trial reportChest2022

Differential Effects of Electronic Hookah Vaping and Traditional Combustible Hookah Smoking on Oxidation, Inflammation, and Arterial Stiffness.

Mary Rezk-Hanna, Rajat Gupta, Charlie O Nettle, Daniel Dobrin, Chiao-Wei Cheng, Angelica Means, Mary-Lynn Brecht, Donald P Tashkin, Jesus A Araujo

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Chest, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03690427 (Investigating the Cardiovascular Toxicity of Exposure to Electronic Hookah Smoking), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03690427 nacompletednot on this map

Investigating the Cardiovascular Toxicity of Exposure to Electronic Hookah Smoking

TypeinterventionalSponsorUniversity of California, Los AngelesRan2018 to 2021Enrolled19ConditionsEndothelial Dysfunction, Inflammation, Oxidative StressArmsTraditional hookah smoking, Electronic hookah vaping
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Chemical Constituents and Particle Size Distribution of Mainstream Emission From Electronic Waterpipe.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Mary Rezk-HannaSchool of Nursing, University of California, Los Angeles, CA. Electronic address: mrezk@ucla.edu.
Rajat GuptaDivision of Cardiology Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA.
Charlie O NettleSchool of Nursing, University of California, Los Angeles, CA.
Daniel DobrinSchool of Nursing, University of California, Los Angeles, CA.
Chiao-Wei ChengSchool of Nursing, University of California, Los Angeles, CA.
Angelica MeansSchool of Nursing, University of California, Los Angeles, CA.
Mary-Lynn BrechtSchool of Nursing, University of California, Los Angeles, CA.
Donald P TashkinDivision of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA.
Jesus A AraujoDivision of Cardiology Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA; Molecular Biology Institute, University of California, Los Angeles, CA; Department of Environmental Health Sciences, Fielding School of Public Health, University of California, Los Angeles, CA.
University of California, Los Angeles · USCedars-Sinai Smidt Heart Institute · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Research Support CoreP30DA012393 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ST.HELEN, GIDEON · 1999 to 2024
$17.1M
Investigating The Cardiovascular Toxicity Of Exposure To Electronic Hookah SmokingR21HL145002 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI REZK-HANNA, MARY · 2018 to 2019
$414k
NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR001881NHLBI NIH HHS R21 HL145002NIDA NIH HHS P30 DA012393
6 · The paper itself

Abstract

backgroundTraditional hookah smoking has grown quickly to become a global tobacco epidemic. More recently, electronic hookahs (e-hookahs)-vaped through traditional water pipes-were introduced as healthier alternatives to combustible hookah. With combustible tobacco smoking, oxidative stress, inflammation, and vascular stiffness are key components in the development and progression of atherosclerosis. The comparable effects of hookah are unknown. RESEARCH QUESTION: What is the differential acute effect of e-hookah vaping vs combustible hookah smoking on oxidation, inflammation, and arterial stiffness? STUDY DESIGN AND

methodsIn a randomized crossover design study, among a cohort of 17 healthy young adult chronic hookah smokers, we investigated the effect of e-hookah vaping and hookah smoking on measures of conduit arterial stiffness, including carotid-femoral pulse wave velocity (PWV), augmentation index-corrected for heart rate before and after a 30-min exposure session. We assessed a panel of circulating biomarkers indicative of inflammation and oxidants and measured plasma nicotine and exhaled carbon monoxide (CO) levels before and after the sessions.

resultse-Hookah vaping tended to lead to a larger acute increase in PWV than hookah smoking (mean ± SE: e-hookah, +0.74 ± 0.12 m/s; combustible hookah, +0.57 ± 0.14 m/s [P < .05 for both]), indicative of large artery stiffening. Compared with baseline, only e-hookah vaping induced an acute increase in augmentation index (e-hookah, +5.58 ± 1.54% [P = .004]; combustible hookah, +2.87 ± 2.12% [P = not significant]). These vascular changes were accompanied by elevation of the proinflammatory biomarkers high-sensitivity C-reactive protein, fibrinogen, and tumor necrosis factor α after vaping (all P < .05). No changes in biomarkers of inflammation and oxidants were observed after smoking. Compared with baseline, exhaled CO levels were higher after smoking than after vaping (+36.81 ± 6.70 parts per million vs -0.38 ± 0.22 parts per million; P < .001), whereas plasma nicotine concentrations were comparable (+6.14 ± 1.03 ng/mL vs +5.24 ± 0.96 ng/mL; P = .478).

interpretationAlthough advertised to be "safe," flavored e-hookah vaping exerts injurious effects on the vasculature that are, at least in part, mediated by inflammation. TRIAL REGISTRY: ClinicalTrials.gov; No.: NCT03690427; URL: www.clinicaltrials.gov.

Indexed as

Carotid-Femoral Pulse Wave VelocityAdultAntioxidantsAryldialkylphosphataseCarbon MonoxideCarboxylic Ester HydrolasesCarotid ArteriesC-Reactive ProteinCross-Over StudiesElectronic Nicotine Delivery SystemsFemaleFemoral ArteryFibrinogenHumansInflammationMaleAntioxidantsAryldialkylphosphatasearylesteraseCarbon MonoxideCarboxylic Ester HydrolasesC-Reactive ProteinFibrinogenNicotinePON1 protein, humanTNF protein, humanTumor Necrosis Factor-alphaarterial stiffnesselectronic hookahelectronic water pipehookah smokinginflammationoxidation

Identifiers

PMID34298007
PMCPMC8783031
OpenAlexW3184209500

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.