Evidence map›Paper›PMID 34298005›Full record

Trial reportChest2021

Prenatal and Postnatal Household Air Pollution Exposures and Pneumonia Risk: Evidence From the Ghana Randomized Air Pollution and Health Study.

Patrick L Kinney, Kwaku-Poku Asante, Alison G Lee, Kenneth A Ae-Ngibise, Katrin Burkart, Ellen Boamah-Kaali, Mieks Twumasi, Stephaney Gyaase, Ashlinn Quinn, Felix B Oppong and 6 more

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Chest, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01335490 (Intervening to Improve Birth Weight and Infant Respiratory Health in Rural Ghana), which is not on this map. Cited by 30 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 3 pooled it
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01335490 nacompletednot on this map

Intervening to Improve Birth Weight and Infant Respiratory Health in Rural Ghana

TypeinterventionalSponsorColumbia UniversityRan2013 to 2016Enrolled1,414ConditionsVery Low Birth Weight Baby, PneumoniaArmsCook stoves, either Biolite wood stove, or liquified petroleum gas stove plus fuel
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 9 institutions in 2 countries.

Patrick L KinneyDepartment of Environmental Health, Boston University School of Public Health, Boston, MA. Electronic address: pkinney@bu.edu.
Kwaku-Poku AsanteKintampo Health Research Centre, Ghana Health Service, Brong Ahafo Region, Kintampo, Ghana.
Alison G LeeDivision of Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Kenneth A Ae-NgibiseKintampo Health Research Centre, Ghana Health Service, Brong Ahafo Region, Kintampo, Ghana.
Katrin BurkartInstitute for Health Metrics and Evaluation, University of Washington, Seattle, WA.
Ellen Boamah-KaaliKintampo Health Research Centre, Ghana Health Service, Brong Ahafo Region, Kintampo, Ghana.
Mieks TwumasiKintampo Health Research Centre, Ghana Health Service, Brong Ahafo Region, Kintampo, Ghana.
Stephaney GyaaseKintampo Health Research Centre, Ghana Health Service, Brong Ahafo Region, Kintampo, Ghana.
Ashlinn QuinnFogarty International Center, National Institutes of Health, Bethesda, MD.
Felix B OppongKintampo Health Research Centre, Ghana Health Service, Brong Ahafo Region, Kintampo, Ghana.
Blair J WylieDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA.
Seyram KaaliKintampo Health Research Centre, Ghana Health Service, Brong Ahafo Region, Kintampo, Ghana.
Steven ChillrudLamont-Doherty Earth Observatory, Columbia University, Palisades, NY.
Abena YawsonKintampo Health Research Centre, Ghana Health Service, Brong Ahafo Region, Kintampo, Ghana.
Darby W JackDepartment of Environmental Health Sciences, Mailman School of Public Health at Columbia University, New York, NY.
Seth Owusu-AgyeiKintampo Health Research Centre, Ghana Health Service, Brong Ahafo Region, Kintampo, Ghana.
Kintampo Health Research Centre · GHGhana Health Service · GHBeth Israel Deaconess Medical Center · USBoston University · USColumbia University · USIcahn School of Medicine at Mount Sinai · USLamont-Doherty Earth Observatory · USNational Institutes of Health · USUniversity of Washington · US

Funding

True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MATTHEW S PERZANOWSKI · 1998 to 2026
$44.7M
Intervening to Improve Birth Weight and Infant Respiratory Health in Rural GhanaR01ES019547 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KINNEY, PATRICK LOTT · 2011 to 2016
$4.5M
Household air pollution in Tanzania, placental health and pregnancy outcomeK23ES021471 · NIEHS · MASSACHUSETTS GENERAL HOSPITAL · PI WYLIE, BLAIR JOHNSON · 2012 to 2016
$1.3M
Prenatal PM2.5 and programming of respiratory outcomes: Placental biomarkers and effect modification by stressK23HL135349 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LEE, ALISON G · 2017 to 2021
$884k
NHLBI NIH HHS K23 HL135349NIEHS NIH HHS K23 ES021471NIEHS NIH HHS P30 ES009089NIEHS NIH HHS R01 ES019547
6 · The paper itself

Abstract

backgroundNearly 40% of the world's population is exposed daily to household air pollution. The relative impact of prenatal and postnatal household air pollution exposure on early childhood pneumonia, a leading cause of mortality, is unknown. RESEARCH QUESTION: Are prenatal or postnatal household air pollution, or both, associated with pneumonia risk in the first year of life? STUDY DESIGN AND

methodsThe Ghana Randomized Air Pollution and Health Study enrolled 1,414 nonsmoking, pregnant women before 24 weeks' gestation with prospective follow-up to the child's age of 1 year. We measured 72-h personal household air pollution exposures, indexed by carbon monoxide (CO), four times prenatally and three times postnatally. Weekly fieldworker surveillance identified ill-appearing children for physician pneumonia assessment. We used quasi-Poisson models to examine associations between prenatal and postnatal CO and physician-diagnosed pneumonia and severe pneumonia. Sex-specific effects were examined.

resultsOf the 1,306 live births, 1,141 infants were followed up with 55,605 child-weeks of fieldworker surveillance. The estimated risk for pneumonia and severe pneumonia in the first year of life increased by 10% (relative risk [RR], 1.10; 95% CI, 1.04-1.16) and 15% (RR, 1.15; 95% CI, 1.03-1.28), respectively, per 1-part per million (ppm) increase in average prenatal CO exposure and by 6% (RR, 1.06; 95% CI, 0.99-1.13) per 1-ppm increase in average postnatal CO exposure. Sex-stratified analyses suggest that in girls, higher prenatal CO exposure was associated with pneumonia risk, while no association was seen in boys.

interpretationPrenatal household air pollution exposure increased risk of pneumonia and severe pneumonia in the first year of life. Clean-burning interventions may be most effective when begun prenatally. TRIAL REGISTRY: ClinicalTrials.gov; No.: NCT01335490; URL: www.clinicaltrials.gov.

Indexed as

Air Pollution, IndoorEnvironmental ExposureInfant HealthPneumoniaCarbon MonoxideFemaleGhanaHousehold ArticlesHumansInfantMaleNeeds AssessmentParticulate MatterPerinatal CarePregnancyPreventive Health ServicesCarbon MonoxideParticulate Matterhousehold air pollutionpneumoniaprenatal and postnatal exposuressex-specific effects

Identifiers

PMID34298005
PMCPMC8628168
OpenAlexW3183180735

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.