Evidence map›Paper›PMID 34297939›Full record

ArticleStem cell reports2021

Hypersensitivity response has negligible impact on Hematopoietic Stem Cells.

Nir Bujanover, Roshina Thapa, Oron Goldstein, Leonid Olender, Omri Sharabi, Michael D Milsom, Roi Gazit

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Rapid activation of hematopoietic stem cells.Stem cell research & therapy · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Nir BujanoverThe Shraga Segal Department of Microbiology Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, 84105, Israel; National Institute for Biotechnology in the Negev, 84105, Israel.
Roshina ThapaThe Shraga Segal Department of Microbiology Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, 84105, Israel; National Institute for Biotechnology in the Negev, 84105, Israel.
Oron GoldsteinThe Shraga Segal Department of Microbiology Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, 84105, Israel; National Institute for Biotechnology in the Negev, 84105, Israel; Center for Regenerative Medicine and Stem Cells, Ben-Gurion University of the Negev, 84105, Israel.
Leonid OlenderThe Shraga Segal Department of Microbiology Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, 84105, Israel; National Institute for Biotechnology in the Negev, 84105, Israel.
Omri SharabiThe Shraga Segal Department of Microbiology Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, 84105, Israel; National Institute for Biotechnology in the Negev, 84105, Israel.
Michael D MilsomHeidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Division of Experimental Hematology, Deutsches Krebsforschungszentrum (DKFZ) and DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany.
Roi GazitThe Shraga Segal Department of Microbiology Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, 84105, Israel; National Institute for Biotechnology in the Negev, 84105, Israel; Center for Regenerative Medicine and Stem Cells, Ben-Gurion University of the Negev, 84105, Israel. Electronic address: gazitroi@bgu.ac.il.
Ben-Gurion University of the Negev · ILGerman Cancer Research Center · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune cells are generated from hematopoietic stem cells (HSCs) in the bone marrow (BM). Immune stimulation can rapidly activate HSCs out of their quiescent state to accelerate the generation of immune cells. HSCs' activation follows various viral or bacterial stimuli, and we sought to investigate the hypersensitivity immune response. Surprisingly, the Ova-induced hypersensitivity peritonitis model finds no significant changes in BM HSCs. HSC markers cKIT, SCA1, CD48, CD150, and the Fgd5-mCherry reporter showed no significant difference from control. Functionally, hypersensitivity did not alter HSCs' potency, as assayed by transplantation. We further characterized the possible impact of hypersensitivity using RNA-sequencing of HSCs, finding minor changes at the transcriptome level. Moreover, hypersensitivity induced no significant change in the proliferative state of HSCs. Therefore, this study suggests that, in contrast to other immune stimuli, hypersensitivity has no impact on HSCs.

Indexed as

Adaptive ImmunityAnimalsAtaxin-1Bone Marrow CellsCD48 AntigenCell DifferentiationHematopoietic Stem CellsHematopoietic Stem Cell TransplantationHypersensitivityMiceMice, CongenicMice, Inbred C57BLMice, TransgenicProto-Oncogene Proteins c-kitRNA-SeqTranscriptomeAtaxin-1Atxn1 protein, mouseCD48 AntigenCd48 protein, mouseKit protein, mouseProto-Oncogene Proteins c-kitdormancyhematopoietic stem cellshypersensitivityimmune responsequiescence

Identifiers

PMID34297939
PMCPMC8365095
OpenAlexW3184891323

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.