Evidence map›Paper›PMID 34297895›Full record

Trial reportAlzheimer's & dementia : the journal of the Alzheimer's Association2021

Recruitment of a multi-site randomized controlled trial of aerobic exercise for older adults with amnestic mild cognitive impairment: The EXERT trial.

Aladdin H Shadyab, Andrea Z LaCroix, Howard H Feldman, Christopher H van Dyck, Ozioma C Okonkwo, Steven P Tam, J Kaci Fairchild, Kathleen A Welsh-Bohmer, Genevieve Matthews, Daniel Bennett and 10 more

Open access · hybridAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 1 country.

Aladdin H ShadyabHerbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla, California, USA.ORCID 0000-0002-9693-0522
Andrea Z LaCroixHerbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla, California, USA.
Howard H FeldmanDepartment of Neurosciences, Alzheimer's Disease Cooperative Study, University of California, San Diego, La Jolla, California, USA.
Christopher H van DyckDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.
Ozioma C OkonkwoSchool of Medicine and Public Health, Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Steven P TamUniversity of California, Irvine School of Medicine, Irvine, California, USA.
J Kaci FairchildDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA.
Kathleen A Welsh-BohmerDepartment of Neurology, Bryan Alzheimer's Disease Research Center, Duke University School of Medicine, Durham, North Carolina, USA.
Genevieve MatthewsDepartment of Neurosciences, Alzheimer's Disease Cooperative Study, University of California, San Diego, La Jolla, California, USA.
Daniel BennettDepartment of Neurosciences, Alzheimer's Disease Cooperative Study, University of California, San Diego, La Jolla, California, USA.
Alexandre A ShadyabDepartment of Neurosciences, Alzheimer's Disease Cooperative Study, University of California, San Diego, La Jolla, California, USA.
Kimberly A SchaferDepartment of Neurosciences, Alzheimer's Disease Cooperative Study, University of California, San Diego, La Jolla, California, USA.
Rosemary H MorrisonDepartment of Neurosciences, Alzheimer's Disease Cooperative Study, University of California, San Diego, La Jolla, California, USA.
Sean A KippermanDepartment of Neurosciences, Alzheimer's Disease Cooperative Study, University of California, San Diego, La Jolla, California, USA.
Jennifer MasonDepartment of Neurosciences, Alzheimer's Disease Cooperative Study, University of California, San Diego, La Jolla, California, USA.
Donna TanDepartment of Neurosciences, Alzheimer's Disease Cooperative Study, University of California, San Diego, La Jolla, California, USA.
Ronald G ThomasHerbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla, California, USA.
Carl W CotmanInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, California, USA.
Laura D BakerDepartment of Internal Medicine-Geriatrics, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
ADCS EXERT Study Group
University of California San Diego · USUniversity of California, Irvine · USUniversity of Wisconsin–Madison · USDuke University · USWake Forest University · USYale University · US

Funding

RECRUITMENT COREU19AG010483 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FELDMAN, HOWARD · 2013 to 2020
$80.6M
Yale Alzheimer Disease Research CenterP30AG066508 · NIA · YALE UNIVERSITY · PI STEPHEN M STRITTMATTER · 2020 to 2026
$30.2M
Wake Forest Alzheimer's Disease Core CenterP30AG049638 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI WILLIAMSON, JEFF DOUGLAS · 2016 to 2020
$12.2M
Epigenetic suppression of histone methylation reverses age and AD-related cognitive declineRF1AG057558 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI WOOD, MARCELO ANDRES · 2018 to 2018
$3.8M
NIA NIH HHS P30 AG049638NIA NIH HHS P30 AG066508NIA NIH HHS RF1 AG057558NIA NIH HHS U19 AG010483
6 · The paper itself

Abstract

introductionEffective strategies to recruit older adults with mild cognitive impairment (MCI) into nonpharmacological intervention trials are lacking.

methodsRecruitment for EXERT, a multisite randomized controlled 18-month trial examining the effects of aerobic exercise on cognitive trajectory in adults with amnestic MCI, involved a diverse portfolio of strategies to enroll 296 participants.

resultsRecruitment occurred September 2016 through March 2020 and was initially slow. After mass mailings of 490,323 age- and geo-targeted infographic postcards and brochures, recruitment rates increased substantially, peaking at 16 randomizations/month in early 2020. Mass mailings accounted for 52% of randomized participants, whereas 25% were recruited from memory clinic rosters, electronic health records, and national and local registries. Other sources included news broadcasts, public service announcements (PSA), local advertising, and community presentations. DISCUSSION: Age- and geo-targeted mass mailing of infographic materials was the most effective approach in recruiting older adults with amnestic MCI into an 18-month exercise trial.

Indexed as

ExercisePamphletsPatient SelectionAgedAmnesiaCognitionCognitive DysfunctionFemaleHumansMalePostal ServiceAlzheimer's diseaseclinical trialexerciselifestyle interventionmild cognitive impairmentnonpharmacologicalrecruitment

Identifiers

PMID34297895
PMCPMC9292825
OpenAlexW3112696990

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.