Evidence map›Paper›PMID 34297878›Full record

ArticleClinical transplantation2021

Operational challenges in the COVID-19 era: Asymptomatic infections and vaccination timing.

David A Axelrod, Dilek Ince, Meera N Harhay, Roslyn B Mannon, Tarek Alhamad, Matthew Cooper, Michelle A Josephson, Yasar Caliskan, Asif Sharfuddin, Vineeta Kumar and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Clinical transplantation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. An overview of COVID-19 in solid organ transplantation.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2022
    Review
  11. Survey of current transplant center practices regarding COVID-19 vaccine mandates in the United States.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022
    Article
  12. COVID-19 vaccination timing and kidney transplant waitlist management: An international perspective.Transplant infectious disease : an official journal of the Transplantation Society · 2022
    Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 1 country.

David A AxelrodOrgan Transplant Center, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.ORCID 0000-0001-5684-0613
Dilek InceOrgan Transplant Center, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.ORCID 0000-0001-5446-3789
Meera N HarhayDrexel University Tower Health Transplant Institute, Philadelphia, Pennsylvania, USA.
Roslyn B MannonUniversity of Nebraska, Omaha, Nebraska, USA.ORCID 0000-0003-1776-3680
Tarek AlhamadWashington University, St. Louis, Missouri, USA.
Matthew CooperMedstar Georgetown Transplant Institute, Washington, District of Columbia, USA.
Michelle A JosephsonUniversity of Chicago, Chicago, Illinois, USA.
Yasar CaliskanSaint Louis University Center for Abdominal Transplantation, St. Louis, Missouri, USA.
Asif SharfuddinIndiana University, Indianapolis, Indiana, USA.
Vineeta KumarUniversity of Alabama at Birmingham, Birmingham, Alabama, USA.
Alexis GuenetteSaint Louis University Center for Abdominal Transplantation, St. Louis, Missouri, USA.
Mark A SchnitzlerSaint Louis University Center for Abdominal Transplantation, St. Louis, Missouri, USA.
Sruthi AinapurapuSaint Louis University Center for Abdominal Transplantation, St. Louis, Missouri, USA.
Krista L LentineSaint Louis University Center for Abdominal Transplantation, St. Louis, Missouri, USA.ORCID 0000-0002-9423-4849
Saint Louis University · USUniversity of Iowa Hospitals and Clinics · USDrexel University · USIndiana University Indianapolis · USMedStar Heart & Vascular Institute · USUniversity of Alabama at Birmingham · USUniversity of Chicago · USUniversity of Nebraska at Omaha · USWashington University in St. Louis · US

Funding

Living Donor Extended Time Outcomes (LETO) StudyR01DK120551 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HSU, CHI-YUAN, LENTINE, KRISTA L · 2019 to 2023
$3.9M
NIDDK NIH HHS R01 DK120551
6 · The paper itself

Abstract

The coronavirus disease 2019 (COVID-19) pandemic has created unprecedented challenges for solid organ transplant programs. While transplant activity has largely recovered, appropriate management of deceased donor candidates who are asymptomatic but have positive nucleic acid testing (NAT) for SARS-CoV-2 is unclear, as this result may reflect active infection or prolonged viral shedding. Furthermore, candidates who are unvaccinated or partially vaccinated continue to receive donor offers. In the absence of robust outcomes data, transplant professionals at US adult kidney transplant centers were surveyed (February 13, 2021 to April 29, 2021) to determine community practice (N: 92 centers, capturing 41% of centers and 57% of transplants performed). The majority (97%) of responding centers declined organs for asymptomatic NAT+ patients without documented prior infection. However, 32% of centers proceed with kidney transplant in NAT+ patients who were at least 30 days from initial diagnosis with negative chest imaging. Less than 7% of programs reported inactivating patients who were unvaccinated or partially vaccinated. In conclusion, despite national recommendations to wait for negative testing, many centers are proceeding with kidney transplant in patients with positive SARS-CoV-2 NAT results due to presumed viral shedding. Furthermore, few centers are requiring COVID-19 vaccination prior to transplantation at this time.

Indexed as

COVID-19AdultAsymptomatic InfectionsCOVID-19 VaccinesHumansSARS-CoV-2VaccinationCOVID-19 VaccinesCOVID-19kidney transplantationoffer acceptancepandemicpracticesvaccinationwaitlist management

Identifiers

PMID34297878
PMCPMC8420523
OpenAlexW3183466067

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.