ArticleCerebral cortex (New York, N.Y. : 1991)2021
Lost Dynamics and the Dynamics of Loss: Longitudinal Compression of Brain Signal Variability is Coupled with Declines in Functional Integration and Cognitive Performance.
Article in Cerebral cortex (New York, N.Y. : 1991), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Within-Individual BOLD Signal Variability and its Implications for Task-Based Cognition: A Systematic Review.Neuropsychology review · 2024Pooled it
- Brain signal variability during rest as a neural mechanism underlying cognitive reserve.NeuroImage · 2026Article
- Thalamocortical network dynamics in focal epilepsy: SEEG investigation.bioRxiv : the preprint server for biology · 2026Article
- The biological role of local and global fMRI BOLD signal variability in multiscale human brain organization.Nature communications · 2026Article
- Review
- Broadscale dampening of uncertainty adjustment in the aging brain.Nature communications · 2024Article
- Differential involvement of central and peripheral catecholamines between Alzheimer's disease and vascular dementia.Heliyon · 2024Article
- Protocol and preregistration for the CODEC project: measuring, modelling and mechanistically understanding the nature of cognitive variability in early childhood.BMC psychology · 2024Article
- Linking Cognitive Integrity to Working Memory Dynamics in the Aging Human Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Brain signal variability and executive functions across the life span.Network neuroscience (Cambridge, Mass.) · 2024Article
- Neural variability in three major psychiatric disorders.Molecular psychiatry · 2023Article
- Relation of resting brain signal variability to cognitive and socioemotional measures in an adult lifespan sample.Social cognitive and affective neuroscience · 2023Article
- The impact of the human thalamus on brain-wide information processing.Nature reviews. Neuroscience · 2023Review
- From local properties to brain-wide organization: A review of intraregional temporal features in functional magnetic resonance imaging data.Human brain mapping · 2023Review
- Poorer White Matter Microstructure Predicts Slower and More Variable Reaction Time Performance: Evidence for a Neural Noise Hypothesis in a Large Lifespan Cohort.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Individual functional parcellation revealed compensation of dynamic limbic network organization in healthy ageing.Human brain mapping · 2023Article
- Signal Variability and Cognitive Function in Older Long-Term Survivors of Breast Cancer with Exposure to Chemotherapy: A Prospective Longitudinal Resting-State fMRI Study.Brain sciences · 2022Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
Reduced moment-to-moment blood oxygen level-dependent (BOLD) signal variability has been consistently linked to advanced age and poorer cognitive performance, showing potential as a functional marker of brain aging. To date, however, this promise has rested exclusively on cross-sectional comparisons. In a sample of 74 healthy adults, we provide the first longitudinal evidence linking individual differences in BOLD variability, age, and performance across multiple cognitive domains over an average period of 2.5 years. As expected, those expressing greater loss of BOLD variability also exhibited greater decline in cognition. The fronto-striato-thalamic system emerged as a core neural substrate for these change-change associations. Preservation of signal variability within regions of the fronto-striato-thalamic system also cohered with preservation of functional integration across regions of this system, suggesting that longitudinal maintenance of "local" dynamics may require across-region communication. We therefore propose this neural system as a primary target in future longitudinal studies on the neural substrates of cognitive aging. Given that longitudinal change-change associations between brain and cognition are notoriously difficult to detect, the presence of such an association within a relatively short follow-up period bolsters the promise of brain signal variability as a viable, experimentally sensitive probe for studying individual differences in human cognitive aging.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.