Evidence map›Paper›PMID 34297764›Full record

ArticlePloS one2021

Construction and validation of an ultraviolet germicidal irradiation system using locally available components.

Eric Schnell, Elham Karamooz, Melanie J Harriff, Jane E Yates, Christopher D Pfeiffer, Stephen M Smith

Open access · goldAbstract readValidation Study
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Removal of virus aerosols by the combination of filtration and UV-C irradiation.Frontiers of environmental science & engineering · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Eric SchnellOperative Care Division, VA Portland Health Care System, Portland, OR, United States of America.ORCID 0000-0002-5623-5015
Elham KaramoozPulmonary and Critical Care Medicine, VA Portland Health Care System, Portland, OR, United States of America.
Melanie J HarriffPulmonary and Critical Care Medicine, OHSU, Portland, OR, United States of America.
Jane E YatesResearch and Development, VA Portland Health Care System, Portland, OR, United States of America.
Christopher D PfeifferInfectious Diseases Section, VA Portland Health Care System, Portland, OR, United States of America.
Stephen M SmithPulmonary and Critical Care Medicine, VA Portland Health Care System, Portland, OR, United States of America.ORCID 0000-0002-0331-7615
VA Portland Health Care System · US

Funding

Distinct pathways for MR1 antigen presentation upon infection with intracellular versus extracellular pathogensR01AI129976 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI HARRIFF, MELANIE J · 2017 to 2021
$1.9M
MR1-dependent presentation of Mycobacterium tuberculosis: a unique role for calcium signalingK08AI153359 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI KARAMOOZ, ELHAM · 2020 to 2024
$925k
Sodium channel control of neuronal excitabilityR01GM134110 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI SMITH, STEPHEN M · 2020 to 2022
$652k
Calcium Signaling in MR1-Dependent Antigen PresentationR21AI151079 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI KARAMOOZ, ELHAM · 2020 to 2021
$424k
Microglial control of post-ischemic neurogenesisR21NS102948 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI KOERNER, INES PIA, SCHNELL, ERIC · 2018 to 2019
$418k
Impact of COPD on Lung-Resident MAIT Cell Frequency, Function and Recognition of Bacterial InfectionI01CX001562 · VA · PORTLAND VA MEDICAL CENTER · PI HARRIFF, MELANIE J · 2018 to 2021
–
Control of Circuit Hyperexcitability by Endogenous Opioids in EpilepsyI01BX004938 · VA · PORTLAND VA MEDICAL CENTER · PI SCHNELL, ERIC · 2020 to 2023
–
Dynamic Chemical Regulation of Voltage-gated Sodium ChannelsI01BX002547 · VA · PORTLAND VA MEDICAL CENTER · PI Stephen M Smith · 2015 to 2026
–
BLRD VA I01 BX002547BLRD VA I01 BX002949BLRD VA I01 BX004938CSRD VA I01 CX001562NIAID NIH HHS K08 AI153359NIAID NIH HHS R01 AI129976NIAID NIH HHS R21 AI151079NIGMS NIH HHS R01 GM134110NIH HHS 1R21 AI151079-01NIH HHS 1R21 NS102948NINDS NIH HHS R21 NS102948
6 · The paper itself

Abstract

Coronavirus disease (COVID-19), the disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, is responsible for a global pandemic characterized by high transmissibility and morbidity. Healthcare workers (HCWs) are at risk of contracting COVID-19, but this risk has been mitigated through the use of personal protective equipment such as N95 Filtering Facepiece Respirators (FFRs). At times the high demand for FFRs has exceeded supply, placing HCWs at increased exposure risk. Effective FFR decontamination of many FFR models using ultraviolet-C germicidal irradiation (UVGI) has been well-described, and could maintain respiratory protection for HCWs in the face of supply line shortages. Here, we detail the construction of an ultraviolet-C germicidal irradiation (UVGI) device using previously existing components available at our institution. We provide data on UV-C dosage delivered with our version of this device, provide information on how users can validate the UV-C dose delivered in similarly constructed systems, and describe a simple, novel methodology to test its germicidal effectiveness using in-house reagents and equipment. As similar components are readily available in many hospitals and industrial facilities, we provide recommendations on the local construction of these systems, as well as guidance and strategies towards successful institutional implementation of FFR decontamination.

Indexed as

COVID-19DisinfectionN95 RespiratorsPandemicsSARS-CoV-2Ultraviolet RaysHumans

Identifiers

PMID34297764
PMCPMC8301618
OpenAlexW3183477201

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.