Evidence map›Paper›PMID 34297566›Full record

ArticleJournal of the American Chemical Society2021

Fast Ion-Chelate Dissociation Rate for

Nishanth D Tirukoti, Liat Avram, Talia Haris, Benjamin Lerner, Yael Diskin-Posner, Hyla Allouche-Arnon, Amnon Bar-Shir

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. New Fluorescent Dye for the Detection of ZnJournal of fluorescence · 2025
    Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nishanth D TirukotiDepartment of Molecular Chemistry and Materials Science, Weizmann Institute of Science, Rehovot 7610001, Israel.
Liat AvramDepartment of Chemical Research Support, Weizmann Institute of Science, Rehovot 7610001, Israel.ORCID 0000-0001-6535-3470
Talia HarisDepartment of Chemical Research Support, Weizmann Institute of Science, Rehovot 7610001, Israel.
Benjamin LernerDepartment of Molecular Chemistry and Materials Science, Weizmann Institute of Science, Rehovot 7610001, Israel.
Yael Diskin-PosnerDepartment of Chemical Research Support, Weizmann Institute of Science, Rehovot 7610001, Israel.ORCID 0000-0002-9008-8477
Hyla Allouche-ArnonDepartment of Molecular Chemistry and Materials Science, Weizmann Institute of Science, Rehovot 7610001, Israel.
Amnon Bar-ShirDepartment of Molecular Chemistry and Materials Science, Weizmann Institute of Science, Rehovot 7610001, Israel.ORCID 0000-0003-1431-0221

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fast ion-chelate dissociation rates and weak ion-chelate affinities are desired kinetic and thermodynamic features for imaging probes to allow reversible binding and to prevent deviation from basal ionic levels. Nevertheless, such properties often result in poor readouts upon ion binding, frequently result in low ion specificity, and do not allow the detection of a wide range of concentrations. Herein, we show the design, synthesis, characterization, and implementation of a Zn

Indexed as

Magnetic Resonance ImagingAnimalsBrainChelating AgentsIonsMiceMolecular StructureZincChelating AgentsIonsZinc

Identifiers

PMID34297566
PMCPMC8397314

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.