Evidence map›Paper›PMID 34297502›Full record

ArticleProblemy endokrinologii2021

[Clinical and molecular genetic features of 3 family cases of the central precocious puberty, due to

N A Zubkova, A A Kolodkina, N A Makretskaya, P L Okorokov, T V Pogoda, E V Vasiliev, V M Petrov, A N Tiulpakov

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Problemy endokrinologii, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Bioinformatics analysis explores key pathways and hub genes in central precocious puberty.Journal of pediatric endocrinology & metabolism : JPEM · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

N A ZubkovaEndocrinology Research Centre.
A A KolodkinaEndocrinology Research Centre.
N A MakretskayaEndocrinology Research Centre.
P L OkorokovEndocrinology Research Centre.
T V PogodaEndocrinology Research Centre.
E V VasilievEndocrinology Research Centre.
V M PetrovEndocrinology Research Centre.
A N TiulpakovEndocrinology Research Centre; Research Centre for Medical Genetics.
Endocrinology Research Center · RUResearch Centre for Medical Genetics · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gonadotropin-dependent precocious puberty (central) is a condition resulting from the early (up to 8 years in girls and 9 years in boys) reactivation of the hypothalamic-pituitary-gonadal axis. An increase in the secretion of sex steroids by the gonads in this form is a consequence of the stimulation of the sex glands by gonadotropic hormones of the pituitary gland. In the absence of central nervous system abnormalities, CPP is classified as idiopathic and as familial in some cases, emphasizing the genetic origin of this disorder. Loss-of-function mutations in Makorin Ring Finger Protein 3 (MKRN3) are the most common identified genetic cause of central precocious puberty compared to sporadic cases. In the present study we performed the first descrition of 3 family cases of central precocious puberty duo to novel MKRN3 gene mutation detected by NGS in the Russian Federation.

Indexed as

Puberty, PrecociousFemaleGonadsHumansMaleMolecular BiologyMutationUbiquitin-Protein LigasesMKRN3 protein, humanUbiquitin-Protein Ligases

Identifiers

PMID34297502
PMCPMC9753848
OpenAlexW3184478801

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.