Evidence map›Paper›PMID 34297466›Full record

ArticleChemMedChem2021

Stimulation of Ca

Giacomo Sordi, Andrea Goti, Howard S Young, Ilaria Palchetti, Francesco Tadini-Buoninsegni

Open access · hybridAbstract read
In one paragraph

Article in ChemMedChem, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Gene expression regulation by CaCellular & molecular biology letters · 2026
    Pooled it
  2. Article
  3. Neuronal Calcium Signaling and Cytoskeletal Dynamics in Neurodegeneration.International journal of molecular sciences · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Calcium regulation by SERC-A before and during Alzheimer diseaseBiomedica : revista del Instituto Nacional de Salud · 2023
    Article
  13. Article
  14. Article
  15. Stimulation of CaChemMedChem · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Giacomo SordiDepartment of Chemistry "Ugo Schiff", University of Florence, Via della Lastruccia 3-13, 50019, Sesto Fiorentino, Italy.
Andrea GotiDepartment of Chemistry "Ugo Schiff", University of Florence, Via della Lastruccia 3-13, 50019, Sesto Fiorentino, Italy.
Howard S YoungDepartment of Biochemistry, University of Alberta, Edmonton, Alberta, T6G 2H7, Canada.
Ilaria PalchettiDepartment of Chemistry "Ugo Schiff", University of Florence, Via della Lastruccia 3-13, 50019, Sesto Fiorentino, Italy.
Francesco Tadini-BuoninsegniDepartment of Chemistry "Ugo Schiff", University of Florence, Via della Lastruccia 3-13, 50019, Sesto Fiorentino, Italy.
University of Florence · ITUniversity of Alberta · CA

Funding

Structural Determinants of Calcium Pump RegulationR01HL092321 · NHLBI · LOYOLA UNIVERSITY CHICAGO · PI Seth L Robia · 2008 to 2026
$8.9M
New mechanisms of SERCA regulation: Dimerization and MicropeptidesR01HL143816 · NHLBI · LOYOLA UNIVERSITY CHICAGO · PI Seth L Robia, Gianluigi Veglia · 2019 to 2026
$3.6M
Heart and Stroke Foundation of CanadaNHLBI NIH HHS R01 HL092321NHLBI NIH HHS R01 HL143816Regione Toscana Bando Salute 2018 D78D20000870002
6 · The paper itself

Abstract

The sarco(endo)plasmic reticulum Ca

Indexed as

AminoquinolinesBenzamidesDose-Response Relationship, DrugHumansMolecular StructureSarcoplasmic Reticulum Calcium-Transporting ATPasesSmall Molecule LibrariesStructure-Activity RelationshipAminoquinolinesBenzamidesCDN1163Sarcoplasmic Reticulum Calcium-Transporting ATPasesSmall Molecule Librariescalcium translocationdrug-protein interactionsmembrane transporterreconstituted proteoliposomessarcoplasmic reticulum vesicles

Identifiers

PMID34297466
PMCPMC8571031
OpenAlexW3183888225

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.