Evidence map›Paper›PMID 34297414›Full record

ArticleAmerican journal of hematology2021

Cutaneous T-cell lymphomas: 2021 update on diagnosis, risk-stratification, and management.

Alexandra C Hristov, Trilokraj Tejasvi, Ryan A Wilcox

Abstract read
In one paragraph

Article in American journal of hematology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Brentuximab vedotin and radiotherapy for CD30-positive cutaneous T-cell lymphoma - a retrospective multicenter analysis.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2026
    Article
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  6. Review
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  12. Central Nervous System Manifestations of Cutaneous Lymphomas.Current neurology and neuroscience reports · 2025
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
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  19. Review
  20. Advanced Cutaneous Peripheral T-cell Lymphoma-Not Otherwise Specified with Extensive Ulceronecrotic Dyschromic Plaques and Poor OutcomeTurkish journal of haematology : official journal of Turkish Society of Haematology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alexandra C HristovDepartments of Pathology and Dermatology, North Campus Research Complex, Ann Arbor, Michigan, USA.
Trilokraj TejasviDirector Cutaneous Lymphoma program, Department of Dermatology, A. Alfred Taubman Health Care Center, Ann Arbor, Michigan, USA.
Ryan A WilcoxDivision of Hematology/Oncology, Department of Internal Medicine, University of Michigan Rogel Cancer Center, Ann Arbor, Michigan, USA.ORCID 0000-0002-6420-0760

Funding

THE T-CELL RECEPTOR'S ROLE IN T-CELL LYMPHOMA PATHOGENESISR37CA233476 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WILCOX, RYAN A · 2019 to 2025
$2.2M
Notch and GATA-3 as novel therapeutic targets in T-cell lymphomasR01CA236722 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WILCOX, RYAN A · 2020 to 2024
$1.8M
NCI NIH HHS R01 CA236722NCI NIH HHS R37 CA233476NIH HHS R01CA236722NIH HHS R37CA233476
6 · The paper itself

Abstract

disease overviewCutaneous T-cell lymphomas are a heterogenous group of T-cell neoplasms involving the skin, the majority of which may be classified as Mycosis Fungoides (MF) or Sézary Syndrome (SS). DIAGNOSIS: The diagnosis of MF or SS requires the integration of clinical and histopathologic data. RISK-ADAPTED THERAPY: TNMB (tumor, node, metastasis, blood) staging remains the most important prognostic factor in MF/SS and forms the basis for a "risk-adapted," multi-disciplinary approach to treatment. For patients with disease limited to the skin, expectant management or skin-directed therapies is preferred, as both disease-specific and overall survival for these patients is favorable. In contrast, patients with advanced-stage disease with significant nodal, visceral or blood involvement are generally approached with systemic therapies, including biologic-response modifiers, histone deacetylase inhibitors, or antibody-based strategies, in an escalating fashion. In highly-selected patients, allogeneic stem-cell transplantation may be considered, as this may be curative in some patients.

Indexed as

Antineoplastic AgentsDisease ManagementHistone Deacetylase InhibitorsHumansLymphoma, T-Cell, CutaneousMycosis FungoidesNeoplasm StagingPrognosisRisk AssessmentSezary SyndromeSkin NeoplasmsStem Cell TransplantationAntineoplastic AgentsHistone Deacetylase Inhibitors

Identifiers

PMID34297414
PMCPMC8486344

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.