Evidence map›Paper›PMID 34297339›Full record

ArticleWorld journal of pediatrics : WJP2021

Application of Kaiser Sepsis Calculator in culture-positive infants with early onset sepsis.

Gretchen Kopec, Marc Collin, Anirudha Das

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Article in World journal of pediatrics : WJP, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Gretchen KopecDepartment of Neonatology, University of Illinois College of Medicine, Peoria campus, Peoria, USA.
Marc CollinDepartment of Neonatology, MetroHealth Medical Center, Cleveland, USA.
Anirudha DasDepartment of Neonatology, Cleveland Clinic Children's Hospital, 9500 Euclid Avenue, Cleveland, OH, 44195, USA. anirudhdas26@gmail.com.ORCID http://orcid.org/0000-0002-4078-049X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundKaiser Sepsis Calculator (KSC) reduces antibiotic use, testing and intravenous infiltrates but there are concerns about the missed early onset sepsis (EOS) cases. We sought to apply the KSC score for culture-positive infants retrospectively in infants born in the last 10 years in our hospital.

methodsIn a retrospective cohort study, the comparison groups were divided into Group A (no antibiotics recommended by KSC) and Group B (antibiotics recommended).

resultsOverall, 17/24 (71%) infants would have been started on antibiotics per KSC but 7/24 (29%) would not. The initial EOS risk was not significantly different between the groups (Group A vs. Group B: 0.44 vs. 0.76, P = 0.41), but the final risk score was (0.33 vs. 9.41, P < 0.001). In Group A (no antibiotics), 3/7 infants became symptomatic between 9 and 42 hours.

conclusionThere may be a potential delay in starting antibiotics in infants that are asymptomatic at birth while using KSC.

Indexed as

Neonatal SepsisSepsisAnti-Bacterial AgentsHumansInfantInfant, NewbornRetrospective StudiesRisk AssessmentRisk FactorsAnti-Bacterial AgentsBlood cultureEarly onset sepsisEOSKaiser Sepsis CalculatorNeonatal sepsisNeonateNewborn

Identifiers

PMID34297339

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.