Evidence map›Paper›PMID 34297314›Full record

ArticleGeroScience2021

Pterocarpus marsupium extract extends replicative lifespan in budding yeast.

Mitchell B Lee, Michael G Kiflezghi, Mitsuhiro Tsuchiya, Brian Wasko, Daniel T Carr, Priya A Uppal, Katherine A Grayden, Yordanos C Elala, Tu Anh Nguyen, Jesse Wang and 14 more

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Taurine deficiency as a driver of aging.Science (New York, N.Y.) · 2023
    Article
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors at 2 institutions in 1 country.

Mitchell B Lee *Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA.
Michael G Kiflezghi *Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA.
Mitsuhiro TsuchiyaDepartment of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA.
Brian WaskoDepartment of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA.
Daniel T CarrDepartment of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA.
Priya A UppalDepartment of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA.
Katherine A GraydenDepartment of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA.
Yordanos C ElalaDepartment of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA.
Tu Anh NguyenDepartment of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA.
Jesse WangDepartment of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA.
Priya RagostiDepartment of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA.
Sunny NguyenDepartment of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA.
Yan Ting ZhaoDepartment of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA.
Deborah KimDepartment of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA.
Socheata ThonDepartment of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA.
Irika SinhaDepartment of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA.
Thao T TangDepartment of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA.
Ngoc H B TranDepartment of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA.
Thu H B TranDepartment of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA.
Margarete D MooreDepartment of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA.
Mary Ann K LiDepartment of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA.
Karl RodriguezDepartment of Cell Systems and Anatomy, University of Texas Health Sciences Center, San Antonio, TX, USA.
Daniel E L PromislowDepartment of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA.
Matt KaeberleinDepartment of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA. kaeber@uw.edu.ORCID http://orcid.org/0000-0002-1311-3421
University of Washington · USThe University of Texas Health Science Center at San Antonio · US

Funding

University of Washington Nathan Shock Center of Excellence in the Basic Biology of AgingP30AG013280 · NIA · UNIVERSITY OF WASHINGTON · PI Maitreya J Dunham · 1995 to 2026
$27.1M
Neurobehavior, Neuropathology, and Risk Factors in Alzheimer's DiseaseT32AG052354 · NIA · UNIVERSITY OF WASHINGTON · PI Brian C. Kraemer, ELAINE R. PESKIND · 2016 to 2026
$6.7M
Biological Mechanisms of Healthy Aging Training GrantT32AG066574 · NIA · UNIVERSITY OF WASHINGTON · PI David J. Marcinek, Jessica E Young · 2020 to 2026
$5.3M
Emergent properties of signaling network degradation that mediate homeostatic failure during agingR01AG056359 · NIA · UNIVERSITY OF WASHINGTON · PI KAEBERLEIN, MATT, VILLEN, JUDIT · 2017 to 2021
$2.9M
Metabolome-Genome Associations for Determining Mechanisms of Aging in DrosophilaR01AG049494 · NIA · UNIVERSITY OF WASHINGTON · PI PROMISLOW, DANIEL EDWARD · 2015 to 2019
$1.8M
Howard Hughes Medical InstituteNIA NIH HHS P30 AG013280NIA NIH HHS R01 AG049494NIA NIH HHS R01 AG056359NIA NIH HHS T32 AG052354NIA NIH HHS T32 AG066574
6 · The paper itself

Abstract

As the molecular mechanisms of biological aging become better understood, there is growing interest in identifying interventions that target those mechanisms to promote extended health and longevity. The budding yeast Saccharomyces cerevisiae has served as a premier model organism for identifying genetic and molecular factors that modulate cellular aging and is a powerful system in which to evaluate candidate longevity interventions. Here we screened a collection of natural products and natural product mixtures for effects on the growth rate, mTOR-mediated growth inhibition, and replicative lifespan. No mTOR inhibitory activity was detected, but several of the treatments affected growth rate and lifespan. The strongest lifespan shortening effects were observed for green tea extract and berberine. The most robust lifespan extension was detected from an extract of Pterocarpus marsupium and another mixture containing Pterocarpus marsupium extract. These findings illustrate the utility of the yeast system for longevity intervention discovery and identify Pterocarpus marsupium extract as a potentially fruitful longevity intervention for testing in higher eukaryotes.

Indexed as

PterocarpusSaccharomycetalesLongevityPlant ExtractsSaccharomyces cerevisiaePlant ExtractsLifespan-extending interventionsmTOR inhibitorsNatural productsSaccharomyces cerevisiae

Identifiers

PMID34297314
PMCPMC8599564
OpenAlexW3185623718

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.