Evidence map›Paper›PMID 34297301›Full record

ArticleNeurochemical research2021

ALKBH5 Promotes the Proliferation of Glioma Cells via Enhancing the mRNA Stability of G6PD.

Zhifeng Liu, Yonghan Chen, Leilei Wang, Suzhen Ji

Abstract read
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In one paragraph

Article in Neurochemical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 42 citations in OpenAlex.

  1. Review
  2. Review
  3. Targeting G6PD with Benzimidazole and Thiazole Derivatives SuppressesInternational journal of molecular sciences · 2025
    Article
  4. Review
  5. Lactylation of HDAC1 Confers Resistance to Ferroptosis in Colorectal Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
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  18. The Critical Role of RNA mCellular and molecular neurobiology · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Zhifeng LiuDepartment of Neurosurgery, Cangzhou Central Hospital, No. 16, Xinhua West Road, Cangzhou, 061001, Hebei, China. liuzhifengtj@126.com.
Yonghan ChenDepartment of Neurosurgery, Cangzhou Central Hospital, No. 16, Xinhua West Road, Cangzhou, 061001, Hebei, China.
Leilei WangDepartment of Neurosurgery, Cangzhou Central Hospital, No. 16, Xinhua West Road, Cangzhou, 061001, Hebei, China.
Suzhen JiDepartment of Emergency, Cangzhou Central Hospital, Cangzhou, China.
Cangzhou Central Hospital · CN

Funding

scientific research fund project of hebei provincial health commission 20211353
6 · The paper itself

Abstract

This study aims to investigate the biological role of 6-methyladenine (m6A) methylation in inducing the carcinogenesis of glioma and its proliferation. Relative levels of ALKBH5 and glucose-6-phosphate dehydrogenase (G6PD) in glioma tissues and cell lines were determined by quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot. Gain-of-function and loss-of-function approaches were used to investigate the role of ALKBH5 in mediating proliferation and energy metabolism of glioma cells. The regulatory effect of ALKBH5 on G6PD was analyzed using m6A-qRT-PCR. Our results showed that ALKBH5 was upregulated in glioma, which stimulated glioma cells to proliferate. Serving as a m6A eraser, ALKBH5 demethylated the target transcript G6PD and enhanced its mRNA stability, thereby promoting G6PD translation and activating the pentose phosphate pathway (PPP). Collectively, ALKBH5 stimulates glioma cells to proliferate through erasing the m6A methylation of G6PD, which can be utilized as a potential therapeutic target for glioma.

Indexed as

AlkB Homolog 5, RNA DemethylaseBrain NeoplasmsCell Line, TumorCell ProliferationGliomaGlucosephosphate DehydrogenaseHumansRNA StabilityALKBH5 protein, humanAlkB Homolog 5, RNA DemethylaseG6PD protein, humanGlucosephosphate DehydrogenaseALKBH5G6PDGliomam6A modification

Identifiers

PMID34297301
OpenAlexW3183204684

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.