Evidence map›Paper›PMID 34297267›Full record

SynthesisDigestive diseases and sciences2022

Correlation of Autoimmune Pancreatitis and Malignancy: Systematic Review and Meta-Analysis.

Hossein Haghbin, Justin Chuang, Rawish Fatima, Nuruddinkhodja Zakirkhodjaev, Wade Lee-Smith, Muhammad Aziz

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Digestive diseases and sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hossein HaghbinDepartment of Internal Medicine, University of Toledo, Toledo, OH, USA. hoshaq@yahoo.com.ORCID 0000-0001-8947-287X
Justin ChuangDepartment of Internal Medicine, University of Toledo, Toledo, OH, USA.
Rawish FatimaDepartment of Internal Medicine, University of Toledo, Toledo, OH, USA.
Nuruddinkhodja ZakirkhodjaevDepartment of Surgery, Stony Brook Medicine, Stony Brook, NY, USA.
Wade Lee-SmithUniversity of Toledo Libraries, University of Toledo, Toledo, OH, USA.
Muhammad AzizDivision of Gastroenterology and Hepatology, University of Toledo, Toledo, OH, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is conflicting evidence regarding autoimmune pancreatitis (AIP) association with pancreatic and non-pancreatic cancers. Literature lacks data on overall prevalence of malignancies in autoimmune pancreatitis.

aimGiven the lack of definite evidence, we aimed to pool and summarize data from available literature regarding prevalence of different malignancies in AIP.

methodsWe conducted a systematic search of MEDLINE, EMBASE, Cochrane Register of Controlled Trials, and Web of Science through February 16, 2021, to include observational studies assessing the incidence of cancer in AIP. We used the DerSimonian-Laird method with random effects for meta-analysis. Pooled prevalence, 95% confidence interval (CI), and I

resultsA total of 17 studies with 2746 patients were included assessing the prevalence of cancer in AIP. The overall prevalence of cancer in AIP was 9.6% [95% confidence interval (CI), 5.7-13.5%]. The cancers with the highest prevalence in AIP population were gastric and colorectal cancer, with prevalence of 1.3% (95% CI, 0.5-2.1%) and 1.2% (95% CI, 0.6-1.8%), respectively.

conclusionWe demonstrate the prevalence of different cancers in AIP. Inflammatory surge in AIP and subsequent carcinogenesis is one explanation for this association. Moreover, AIP can be a paraneoplastic syndrome manifestation of malignancies.

Indexed as

Autoimmune DiseasesAutoimmune PancreatitisNeoplasmsPancreatitisDiagnosis, DifferentialHumansImmunoglobulin GImmunoglobulin GAutoimmune pancreatitisImmunoglobulin G4-related diseaseInflammationMalignancyMetabolic syndrome

Identifiers

PMID34297267

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.