Evidence map›Paper›PMID 34297242›Full record

ArticleCancer causes & control : CCC2021

Sex differences in associations between birth characteristics and childhood cancers: a five-state registry-linkage study.

Lindsay A Williams, Jeannette Sample, Colleen C McLaughlin, Beth A Mueller, Eric J Chow, Susan E Carozza, Peggy Reynolds, Logan G Spector

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In one paragraph

Article in Cancer causes & control : CCC, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Lindsay A WilliamsDivision of Epidemiology & Clinical Research, Department of Pediatrics, University of Minnesota, MMC 715, 420 Delaware St. S.E, Minneapolis, MN, 55455, USA. lawilliams@umn.edu.ORCID http://orcid.org/0000-0003-3842-4629
Jeannette SampleDivision of Epidemiology & Clinical Research, Department of Pediatrics, University of Minnesota, MMC 715, 420 Delaware St. S.E, Minneapolis, MN, 55455, USA.
Colleen C McLaughlinAlbany College of Pharmacy and Health Sciences, Albany, NY, USA.
Beth A MuellerPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Eric J ChowPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Susan E CarozzaDepartment of Epidemiology and Biostatistics, School of Rural Public Health, Texas A&M Health Science Center, College Station, TX, USA.
Peggy ReynoldsDepartment of Epidemiology and Biostatistics, University of California San Francisco, Berkeley, CA, USA.
Logan G SpectorDivision of Epidemiology & Clinical Research, Department of Pediatrics, University of Minnesota, MMC 715, 420 Delaware St. S.E, Minneapolis, MN, 55455, USA.
University of Minnesota · USAlbany College of Pharmacy and Health Sciences · USFred Hutch Cancer Center · USTexas A&M Health Science Center · USUniversity of California, San Francisco · USUniversity of Washington · US

Funding

Risk of Childhood Cancers Associated With Agricultural *R01CA092670 · NCI · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI CAROZZA, SUSAN E. · 2001 to 2005
$974k
CDC HHS U58DP000783-01NCI NIH HHS N01-CN-05230NCI NIH HHS R01 CA092670NCI NIH HHS R01 CA717450NCI NIH HHS R01 CA92670
6 · The paper itself

Abstract

backgroundThere is a well-recognized male excess in childhood cancer incidence; however, it is unclear whether there is etiologic heterogeneity by sex when defined by epidemiologic risk factors.

methodsUsing a 5-state registry-linkage study (cases n = 16,411; controls n = 69,816), we estimated sex-stratified odds ratios (OR) and 95% confidence intervals (95% CI) between birth and demographic characteristics for 16 pediatric cancers. Evidence of statistical interaction (p-interaction < 0.01) by sex was evaluated for each characteristic in each cancer.

resultsMales comprised > 50% of cases for all cancers, except Wilms tumor (49.6%). Sex interacted with a number of risk factors (all p-interaction < 0.01) including gestational age for ALL (female, 40 vs. 37-39 weeks OR: 0.84, 95% CI 0.73-0.97) and ependymoma (female, 40 vs. 37-39 OR: 1.78, 95% CI 1.14-2.79; female, ≥ 41 OR: 2.01. 95% CI 1.29-3.14), birth order for AML (female,  ≥ 3rd vs. 1st OR: 1.39, 95% CI 1.01-1.92), maternal education for Hodgkin lymphoma (male, any college vs. < high school[HS] OR: 1.47, 95% CI 1.03-2.09) and Wilms tumor (female, any college vs. HS OR: 0.74, 95% CI 0.59-0.93), maternal race/ethnicity for neuroblastoma (male, black vs. white OR: 2.21, 95% CI 1.21-4.03; male, Hispanic vs. white OR: 1.86, 95% CI 1.26-2.75; female, Asian/Pacific Islander vs. white OR: 0.28, 95% CI 0.12-0.69), and paternal age (years) for hepatoblastoma in males (< 24 vs. 25-29 OR: 2.17, 95% CI 1.13-4.19; ≥ 35 vs. 25-29 OR: 2.44, 95% CI 1.28-4.64).

conclusionsThese findings suggest etiologic heterogeneity by sex for childhood cancers for gestational age, maternal education, and race/ethnicity and paternal age.

Indexed as

Kidney NeoplasmsNeuroblastomaChildFemaleHumansIncidenceMaleRegistriesSex CharacteristicsEtiologic heterogeneityPediatric cancerRegistry-based studySex differences

Identifiers

PMID34297242
OpenAlexW3186639447

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.