ReviewNeuroradiology2021
Spontaneous intracranial hypotension: diagnostic and therapeutic workup.
Review in Neuroradiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 86 citations in OpenAlex.
- CSF Flow and Spinal Cord Motion in Patients With Spontaneous Intracranial Hypotension: A Phase Contrast MRI Study.Neurology · 2023Trial
- Brain distortion and cerebrospinal fluid shifts in spontaneous intracranial hypotension.Fluids and barriers of the CNS · 2026Article
- Spontaneous intracranial hypotension: A stepwise diagnostic and therapeutic workflow from a tertiary referral center.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Diagnostic Challenges and Surgical Outcomes of Miyazaki Syndrome: A Report of Two Cases and a Systematic Review.Cureus · 2026Article
- Manual Therapy-Associated Dural Tear Causing Intracranial Hypotension Treated with an Epidural Blood Patch: A Case Report.Journal of clinical medicine · 2026Article
- Modified Ultrafast Dynamic CT Myelography: Method, Outcomes, and Comparison With Noninvasive Imaging.Journal of clinical neurology (Seoul, Korea) · 2026Article
- Recommendations for the diagnosis and treatment of spontaneous intracranial hypotension.La Radiologia medica · 2026Review
- Acute subdural hematoma in spontaneous intracranial hypotension: illustrative case and review of the literature.Brain & spine · 2026Article
- Spontaneous epidural blood patch at T2/3 with resolution of intracranial hypotension.Surgical neurology international · 2026Article
- Parasagittal subdural space: a novel quantitative marker of spontaneous intracranial hypotension syndrome-induced chronic subdural hematoma.BMC medical imaging · 2025Article
- [Myelography-still up to date?]Radiologie (Heidelberg, Germany) · 2025Article
- Article
- Altered brain fluid dynamics in spontaneous intracranial hypotension.Fluids and barriers of the CNS · 2025Observational
- Safety, Sequelae, and Efficacy of Nerve Root Clipping in Patients With Spontaneous Spinal Cerebrospinal Fluid Leaks.Operative neurosurgery (Hagerstown, Md.) · 2025Article
- Intracranial pressure monitoring in patients with spontaneous onset of orthostatic headache.The journal of headache and pain · 2025Observational
- Differential diagnosis of orthostatic dizziness with persistent postural-perceptual dizziness and its underlying mechanisms.Frontiers in neurology · 2025Review
- Reply: Dementia in spontaneous intracranial hypotension: look at the spine.Neuroradiology · 2025Article
- Different Glymphatic Kinetics in Spontaneous Intracranial Hypotension.AJNR. American journal of neuroradiology · 2024Article
- Spinal dementia: Don't miss it, it's treatable.Neuroradiology · 2024Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spontaneous intracranial hypotension (SIH) is an orthostatic headache syndrome with typical MRI findings among which engorgement of the venous sinuses, pachymeningeal enhancement, and effacement of the suprasellar cistern have the highest diagnostic sensitivity. SIH is in almost all cases caused by spinal CSF leaks. Spinal MRI scans showing so-called spinal longitudinal extradural fluid (SLEC) are suggestive of ventral dural tears (type 1 leak) which are located with prone dynamic (digital subtraction) myelography. As around half of the ventral dural tears are located in the upper thoracic spine, additional prone dynamic CT myelography is often needed. Leaking nerve root sleeves typically associated with meningeal diverticulae (type 2 leaks) and CSF-venous fistulas (type 3 leaks) are proven via lateral decubitus dynamic digital subtraction or CT myelography: type 2 leaks are SLEC-positive if the tear is proximal and SLEC-negative if it is distal, and type 3 leaks are always SLEC-negative. Although 30-70% of SIH patients show marked improvement following epidural blood patches applied via various techniques definite cure mostly requires surgical closure of ventral dural tears and surgical ligations of leaking nerve root sleeves associated with meningeal diverticulae or CSF-venous fistulas. For the latter, transvenous embolization with liquid embolic agents via the azygos vein system is a novel and valuable therapeutic alternative.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.