Evidence map›Paper›PMID 34297166›Full record

ReviewCellular and molecular life sciences : CMLS2021

Ultrasonic technologies in imaging and drug delivery.

Yi-Ju Ho, Chih-Chung Huang, Ching-Hsiang Fan, Hao-Li Liu, Chih-Kuang Yeh

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Article
  3. The sonographic characteristics of unicentric castleman disease - a single-center retrospective study.Cancer imaging : the official publication of the International Cancer Imaging Society · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Hymenoptera and biomimetic surfaces: insights and innovations.Beilstein journal of nanotechnology · 2024
    Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Yi-Ju Ho *Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan.
Chih-Chung Huang *Department of Biomedical Engineering, National Cheng Kung University, Tainan, Taiwan.
Ching-Hsiang FanDepartment of Biomedical Engineering, National Cheng Kung University, Tainan, Taiwan.
Hao-Li LiuDepartment of Electrical Engineering, National Taiwan University, Taipei, Taiwan. hlliu@ntu.edu.tw.
Chih-Kuang YehDepartment of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan. ckyeh@mx.nthu.edu.tw.ORCID http://orcid.org/0000-0002-2880-6327
National Cheng Kung University · TWNational Tsing Hua University · TWNational Taiwan University · TW

Funding

Ministry of Science and Technology, Taiwan MOST 107-2221-E-006-024-MY3Ministry of Science and Technology, Taiwan MOST 107-2628-E-006-004-MY3Ministry of Science and Technology, Taiwan MOST 108-2221-E-002-175-MY3Ministry of Science and Technology, Taiwan MOST 108-2221-E-002-176-MY3Ministry of Science and Technology, Taiwan MOST 108-2638-M-002-001-MY2Ministry of Science and Technology, Taiwan MOST 109-2636-E-006-024Ministry of Science and Technology, Taiwan MOST 110-2321-B-002-010Ministry of Science and Technology, Taiwan (TW) MOST 108-2221-E-007-040-MY3Ministry of Science and Technology, Taiwan (TW) MOST 108-2221-E-007-041-MY3National Tsing Hua University 110Q2510E1
6 · The paper itself

Abstract

Ultrasonic technologies show great promise for diagnostic imaging and drug delivery in theranostic applications. The development of functional and molecular ultrasound imaging is based on the technical breakthrough of high frame-rate ultrasound. The evolution of shear wave elastography, high-frequency ultrasound imaging, ultrasound contrast imaging, and super-resolution blood flow imaging are described in this review. Recently, the therapeutic potential of the interaction of ultrasound with microbubble cavitation or droplet vaporization has become recognized. Microbubbles and phase-change droplets not only provide effective contrast media, but also show great therapeutic potential. Interaction with ultrasound induces unique and distinguishable biophysical features in microbubbles and droplets that promote drug loading and delivery. In particular, this approach demonstrates potential for central nervous system applications. Here, we systemically review the technological developments of theranostic ultrasound including novel ultrasound imaging techniques, the synergetic use of ultrasound with microbubbles and droplets, and microbubble/droplet drug-loading strategies for anticancer applications and disease modulation. These advancements have transformed ultrasound from a purely diagnostic utility into a promising theranostic tool.

Indexed as

UltrasonographyBlood-Brain BarrierBrain NeoplasmsContrast MediaDrug CarriersHumansMicrobubblesNeurodegenerative DiseasesContrast MediaDrug CarriersBlood–brain barrier openingDiagnostic ultrasound imagingLocal drug releaseNeuromodulationTumor therapyUltrasound contrast agent

Identifiers

PMID34297166
PMCPMC11072106
OpenAlexW3183564027

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.