Evidence map›Paper›PMID 34297070›Full record

ArticleJAMA network open2021

Methadone Access for Opioid Use Disorder During the COVID-19 Pandemic Within the United States and Canada.

Paul J Joudrey, Zoe M Adams, Paxton Bach, Sarah Van Buren, Jessica A Chaiton, Lucy Ehrenfeld, Mary Elizabeth Guerra, Brynna Gleeson, Simeon D Kimmel, Ashley Medley and 8 more

Open access · goldAbstract readComparative Study
In one paragraph

Article in JAMA network open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
13.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 79 citations in OpenAlex.

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  9. Pilot of Methadone for Recently Incarcerated People with Human Immunodeficiency Virus and Opioid Use in South Africa.Journal of correctional health care : the official journal of the National Commission on Correctional Health Care · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 2 countries.

Paul J JoudreyDepartment of Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
Zoe M AdamsDepartment of Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
Paxton BachBritish Columbia Center on Substance Use, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Sarah Van BurenYale School of Nursing, Orange, Connecticut.
Jessica A ChaitonBritish Columbia Center on Substance Use, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Lucy EhrenfeldYale School of Nursing, Orange, Connecticut.
Mary Elizabeth GuerraDepartment of Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
Brynna GleesonVassar College, Poughkeepsie, New York.
Simeon D KimmelSections of General Internal Medicine and Infectious Diseases, Department of Medicine, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts.
Ashley MedleyYale School of Nursing, Orange, Connecticut.
Wassim MekidecheFaculty of Pharmacy, Université de Montréal, Montréal, Canada.
Maxime PaquetFaculty of Pharmacy, Université de Montréal, Montréal, Canada.
Minhee SungDepartment of Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
Melinda WangDepartment of Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
R O Olivier You KheangFaculty of Pharmacy, Université de Montréal, Montréal, Canada.
Jingxian ZhangDepartment of Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
Emily A WangDepartment of Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
E Jennifer EdelmanDepartment of Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
Yale University · USUniversité de Montréal · CAUniversity of British Columbia · CABoston University · USVassar College · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
MassHEAL - Reducing overdose deaths by 40% (2019-2023)UM1DA049412 · NIDA · BOSTON MEDICAL CENTER · PI SAMET, JEFFREY H. · 2019 to 2023
$82.9M
Yale Drug use, Addiction and HIV Research Scholars (DAHRS)K12DA033312 · NIDA · YALE UNIVERSITY · PI Gail D'Onofrio, Patrick O'Connor · 2013 to 2026
$7.2M
Mentoring the next generation of addiction clinician scientists while responding to the opioid epidemicR25DA037756 · NIDA · UNIVERSITY OF BRITISH COLUMBIA · PI FAIRBAIRN, NADIA · 2014 to 2023
$3.6M
NCATS NIH HHS UL1 TR001863NIDA NIH HHS K12 DA033312NIDA NIH HHS L30 DA052056NIDA NIH HHS R25 DA037756NIDA NIH HHS UM1 DA049412
6 · The paper itself

Abstract

Importance: Methadone access may be uniquely vulnerable to disruption during COVID-19, and even short delays in access are associated with decreased medication initiation and increased illicit opioid use and overdose death. Relative to Canada, US methadone provision is more restricted and limited to specialized opioid treatment programs. Objective: To compare timely access to methadone initiation in the US and Canada during COVID-19. Design, Setting, and Participants: This cross-sectional study was conducted from May to June 2020. Participating clinics provided methadone for opioid use disorder in 14 US states and territories and 3 Canadian provinces with the highest opioid overdose death rates. Statistical analysis was performed from July 2020 to January 2021. Exposures: Nation and type of health insurance (US Medicaid and US self-pay vs Canadian provincial). Main Outcomes and Measures: Proportion of clinics accepting new patients and days to first appointment. Results: Among 268 of 298 US clinics contacted as a patient with Medicaid (90%), 271 of 301 US clinics contacted as a self-pay patient (90%), and 237 of 288 Canadian clinics contacted as a patient with provincial insurance (82%), new patients were accepted for methadone at 231 clinics (86%) during US Medicaid contacts, 230 clinics (85%) during US self-pay contacts, and at 210 clinics (89%) during Canadian contacts. Among clinics not accepting new patients, at least 44% of 27 clinics reported that the COVID-19 pandemic was the reason. The mean wait for first appointment was greater among US Medicaid contacts (3.5 days [95% CI, 2.9-4.2 days]) and US self-pay contacts (4.1 days [95% CI, 3.4-4.8 days]) than Canadian contacts (1.9 days [95% CI, 1.7-2.1 days]) (P < .001). Open-access model (walk-in hours for new patients without an appointment) utilization was reported by 57 Medicaid (30%), 57 self-pay (30%), and 115 Canadian (59%) contacts offering an appointment. Conclusions and Relevance: In this cross-sectional study of 2 nations, more than 1 in 10 methadone clinics were not accepting new patients. Canadian clinics offered more timely methadone access than US opioid treatment programs. These results suggest that the methadone access shortage was exacerbated by COVID-19 and that changes to the US opioid treatment program model are needed to improve the timeliness of access. Increased open-access model adoption may increase timely access.

Indexed as

COVID-19Health Services AccessibilityOpiate Substitution TreatmentPandemicsWaiting ListsAmbulatory Care FacilitiesAnalgesics, OpioidCanadaCross-Sectional StudiesFinancing, PersonalHealth ServicesInsurance, HealthMedicaidMethadoneOpioid-Related DisordersUnited StatesAnalgesics, OpioidMethadone

Identifiers

PMID34297070
PMCPMC8303098
OpenAlexW3184829782

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.