ArticleeLife2021
A transient postnatal quiescent period precedes emergence of mature cortical dynamics.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Implantable bioelectronic outlet.Science advances · 2026Article
- Motor cortex activity during sleep and wake movements sharpens across development but continues to lag the red nucleus.Scientific reports · 2026Article
- Time-resolved phenotyping of seizure evolution in developmental and epileptic encephalopathy: insights and gaps from the CYFIP2 Arg87Cys mouse model.Frontiers in synaptic neuroscience · 2026Review
- Longitudinal tracking of neuronal activity from the same cells in the developing brain using Track2p.eLife · 2025Article
- Implantable bioelectronics for gut electrophysiology.Nature communications · 2025Article
- Subtype- and Layer-Specific Developmental Gradients of Postnatal GABAergic Neurons in the Rodent Barrel Cortex.Developmental neuroscience · 2025Article
- Interictal network dysfunction and cognitive impairment in epilepsy.Nature reviews. Neuroscience · 2025Review
- Spatial control of doping in conducting polymers enables complementary, conformable, implantable internal ion-gated organic electrochemical transistors.Nature communications · 2025Article
- EEG difference in the Higuchi fractal dimension of wakefulness and sleep from birth to adolescence.PloS one · 2025Article
- High-Density, Conformable Conducting Polymer-Based Implantable Neural Probes for the Developing Brain.Advanced healthcare materials · 2024Article
- E-Suture: Mixed-Conducting Suture for Medical Devices.Advanced healthcare materials · 2024Article
- Formation of Anisotropic Conducting Interlayer for High-Resolution Epidermal Electromyography Using Mixed-Conducting Particulate Composite.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Review
- Distinct Features of Interictal Activity Predict Seizure Localization and Burden in a Mouse Model of Childhood Epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- The rapid developmental rise of somatic inhibition disengages hippocampal dynamics from self-motion.eLife · 2022Article
- Anisotropic Ion Conducting Particulate Composites for Bioelectronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Cognitive impairment following experimental febrile seizures is determined by sex and seizure duration.Epilepsy & behavior : E&B · 2022Article
- Movements during sleep reveal the developmental emergence of a cerebellar-dependent internal model in motor thalamus.Current biology : CB · 2021Article
- Bottom-up inputs are required for establishment of top-down connectivity onto cortical layer 1 neurogliaform cells.Neuron · 2021Article
- Article
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Authors and funding
11 authors.
Funding
Abstract
Mature neural networks synchronize and integrate spatiotemporal activity patterns to support cognition. Emergence of these activity patterns and functions is believed to be developmentally regulated, but the postnatal time course for neural networks to perform complex computations remains unknown. We investigate the progression of large-scale synaptic and cellular activity patterns across development using high spatiotemporal resolution in vivo electrophysiology in immature mice. We reveal that mature cortical processes emerge rapidly and simultaneously after a discrete but volatile transition period at the beginning of the second postnatal week of rodent development. The transition is characterized by relative neural quiescence, after which spatially distributed, temporally precise, and internally organized activity occurs. We demonstrate a similar developmental trajectory in humans, suggesting an evolutionarily conserved mechanism that could facilitate a transition in network operation. We hypothesize that this transient quiescent period is a requisite for the subsequent emergence of coordinated cortical networks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.