ArticleJournal of clinical laboratory analysis2021
Circular RNA circβ-catenin aggravates the malignant phenotype of non-small-cell lung cancer via encoding a peptide.
Article in Journal of clinical laboratory analysis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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Who cites it
29 citing papers in PubMed.
- The translational roles of circular RNAs in cancers and their underlying molecular mechanisms.Medical oncology (Northwood, London, England) · 2026Review
- Peptides from the Shadows: Molecular Depth Insights and Clinical Horizons of Circular RNA-encoded Peptides in Gliomas.Neuromolecular medicine · 2026Review
- Functional mechanisms of circular RNA‑encoded peptides and future research strategies and directions in nasopharyngeal carcinoma (Review).International journal of oncology · 2025Review
- Small open reading frame-encoded microproteins in cancer: identification, biological functions and clinical significance.Molecular cancer · 2025Review
- Noncoding RNA-encoded peptides in cancer: biological functions, posttranslational modifications and therapeutic potential.Journal of hematology & oncology · 2025Review
- Translation of circular RNAs.Nucleic acids research · 2025Review
- Circular RNA-Encoded Proteins in Disease Pathogenesis.International journal of biological sciences · 2025Review
- CircRNA and lncRNA-encoded peptide in diseases, an update review.Molecular cancer · 2024Review
- The multifaceted roles of circular RNAs in cancer hallmarks: From mechanisms to clinical implications.Molecular therapy. Nucleic acids · 2024Review
- Coding, or non-coding, that is the question.Cell research · 2024Review
- EIF4A3-negatively driven circular RNA β-catenin (circβ-catenin) promotes colorectal cancer progression via miR-197-3p/CTNND1 regulatory axis.British journal of cancer · 2024Article
- CircYthdc2 generates polypeptides through two translation strategies to facilitate virus escape.Cellular and molecular life sciences : CMLS · 2024Article
- The important regulatory roles of circRNA‑encoded proteins or peptides in cancer pathogenesis (Review).International journal of oncology · 2024Review
- Roles of small peptides encoded by non-coding RNAs in tumor invasion and migration.Frontiers in pharmacology · 2024Review
- Emerging roles and potential clinical applications of translatable circular RNAs in cancer and other human diseases.Genes & diseases · 2023Review
- Newly discovered mechanisms that mediate tumorigenesis and tumour progression: circRNA-encoded proteins.Journal of cellular and molecular medicine · 2023Review
- Circular RNA SPI1 expression before and after induction therapy and its correlation with clinical features, treatment response, and survival of acute myeloid leukemia patients.Journal of clinical laboratory analysis · 2023Article
- Serum circular RNA hsa_circ_0000702 as a novel biomarker for diagnosis of gastric cancer.Journal of clinical laboratory analysis · 2023Article
- The role of 25(OH)D3 and circRNAs in early diagnosis of gestational diabetes mellitus.Journal of clinical laboratory analysis · 2023Article
- Circular RNAs expression profiles and bioinformatics analysis in bronchopulmonary dysplasia.Journal of clinical laboratory analysis · 2023Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundMore and more evidences demonstrate that circular RNAs (circNRAs) can encode protein. As a circRNA with translation capabilities, outcomes of circβ-catenin in non-small cell lung cancer (NSCLC) still need to be explored.
methodThe research methods of circβ-catenin in the article include qRT-PCR, wound healing assay, CCK-8, colony formation, and Transwell assay. Western blotting and immunofluorescence were provided to detect protein expression levels and peptide encoded by circβ-catenin, respectively.
resultsA prominently higher circβ-catenin expression was found in NSCLC tissues. Silencing of circβ-catenin was able to inhibit NSCLC cell migrating, invasive, and proliferative phenotypes. Overexpression of circβ-catenin could enhance the migrating, invasive, and proliferative phenotypes of NSCLC cells. Importantly, circβ-catenin was found to encode a peptide in NSCLC cells. Silencing or overexpression of circβ-catenin could reduce or increase β-catenin protein expression via suppressing the degradation of β-catenin.
conclusionCircβ-catenin could promote NSCLC cell malignant phenotypes via peptide-regulated β-catenin pathway. Our study provided a new understanding for the mechanisms of NSCLC.
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