Evidence map›Paper›PMID 34296774›Full record

ReviewJournal of child psychology and psychiatry, and allied disciplines2022

Annual Research Review: The transdiagnostic revolution in neurodevelopmental disorders.

Duncan E Astle, Joni Holmes, Rogier Kievit, Susan E Gathercole

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Journal of child psychology and psychiatry, and allied disciplines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06877260 (Characterization of Neurocognitive Profiles in Neurodevelopmental Disorders and Epilepsy), which is not on this map. Cited by 171 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
171citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06877260 active not recruitingnot on this mapstarted 2024, after this paper: background citation

Characterization of Neurocognitive Profiles in Neurodevelopmental Disorders and Epilepsy: a Transdiagnostic Approach

TypeobservationalSponsorIRCCS Eugenio MedeaRan2024 to 2027Enrolled60ConditionsNeurodevelopmental Disorder (Diagnosis), EpilepsyArmsComputer based task with EEG
3 · Its place in the literature

Who cites it

171 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Autistic Traits and Camouflaging: A Meta-Analysis.Autism : the international journal of research and practice · 2026
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  16. Sleep in Young Children With Autism, ADHD and Combined Presentations.Autism research : official journal of the International Society for Autism Research · 2026
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  19. Observational
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111 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Duncan E AstleMRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.
Joni HolmesMRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.
Rogier KievitMRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.
Susan E GathercoleMRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.

Funding

Medical Research Council MC-A0606-5PQ41Medical Research Council MC_UP_A060_1103Medical Research Council MC_UU_00005/2Medical Research Council MC_UU_00030/2
6 · The paper itself

Abstract

Practitioners frequently use diagnostic criteria to identify children with neurodevelopmental disorders and to guide intervention decisions. These criteria also provide the organising framework for much of the research focussing on these disorders. Study design, recruitment, analysis and theory are largely built on the assumption that diagnostic criteria reflect an underlying reality. However, there is growing concern that this assumption may not be a valid and that an alternative transdiagnostic approach may better serve our understanding of this large heterogeneous population of young people. This review draws on important developments over the past decade that have set the stage for much-needed breakthroughs in understanding neurodevelopmental disorders. We evaluate contemporary approaches to study design and recruitment, review the use of data-driven methods to characterise cognition, behaviour and neurobiology, and consider what alternative transdiagnostic models could mean for children and families. This review concludes that an overreliance on ill-fitting diagnostic criteria is impeding progress towards identifying the barriers that children encounter, understanding underpinning mechanisms and finding the best route to supporting them.

Indexed as

Neurodevelopmental DisordersAdolescentChildCognitionHumansADHDAutismDevelopmental Language Disorderlearning difficultiesNeurodevelopmental disordersworking memory

Identifiers

PMID34296774

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.