Evidence map›Paper›PMID 34296770›Full record

ArticleNeuropathology and applied neurobiology2022

Pituitary corticotroph tumour with adrenocortical cells: A distinct clinicopathologic entity with unique morphology and methylation profile.

Richard A Hickman, John T Gionco, Phyllis L Faust, Michael L Miller, Jeffrey Bruce, Gabrielle Page-Wilson, Marc K Rosenblum, Sylvia L Asa

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropathology and applied neurobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. DNA Methylation in Pituitary Adenomas: A Scoping Review.International journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Richard A HickmanDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center and New York Presbyterian Hospital, New York, New York, USA.ORCID 0000-0002-8329-6083
John T GioncoDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center and New York Presbyterian Hospital, New York, New York, USA.
Phyllis L FaustDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center and New York Presbyterian Hospital, New York, New York, USA.
Michael L MillerDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center and New York Presbyterian Hospital, New York, New York, USA.
Jeffrey BruceDepartment of Neurological Surgery, Columbia University Irving Medical Center and New York Presbyterian Hospital, New York, New York, USA.
Gabrielle Page-WilsonDepartment of Medicine, Columbia University Irving Medical Center and New York Presbyterian Hospital, New York, New York, USA.
Marc K RosenblumDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Sylvia L AsaDepartment of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
X-RAY STRUCTURE OF RIFM PROTEIN FROM THE BIOSYNTHESIS PATHWAY OF THE ANSAMYCIN AP41RR012408 · NCRR · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI MARIUZZA, ROY A · 1998 to 2011
$32.2M
Rutgers Biotechnology Training ProgramT32GM135141 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI ANN M. STOCK, Martin L Yarmush · 2020 to 2026
$3.5M
NCI NIH HHS P30 CA008748NCRR NIH HHS P41 RR012408NIGMS NIH HHS T32 GM135141
6 · The paper itself

Abstract

We describe a rare TPIT-positive corticotroph PitNET that is admixed with SF1-positive adrenocortical cells. This dimorphous population of cells showed no colocalisation between TPIT and SF1 by immunofluorescence, and an adrenocortical choristoma was favoured. Methylation array analysis revealed a novel methylation profile in relation to other pituitary neoplasms.

Indexed as

DNA MethylationACTH-Secreting Pituitary AdenomaAdultCorticotrophsHumansMalePituitary GlandPituitary Neoplasmsadrenocortical cellschoristomacorticotroph tumour

Identifiers

PMID34296770
PMCPMC9344380

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.