Evidence map›Paper›PMID 34296627›Full record

ArticleInternational journal of immunopathology and pharmacology

Vancomycin and daptomycin modulate the innate immune response in a murine model of LPS-induced sepsis.

Stefan Muenster, Valentina Zschernack, Birte Dierig, Stilla Frede, Georg Baumgarten, Mark Coburn, Christian Putensen, Christina Katharina Weisheit

Open access · goldAbstract read
In one paragraph

Article in International journal of immunopathology and pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Stefan MuensterDepartment of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany.ORCID https://orcid.org/0000-0001-6174-7456
Valentina ZschernackDepartment of Neuropathology, University Hospital Bonn, Bonn, Germany.
Birte DierigDepartment of Cardiac, Thoracic and Vascular Surgery, University Hospital Mainz, Mainz, Germany.
Stilla FredeDepartment of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany.
Georg BaumgartenDepartment of Anesthesiology and Intensive Care, Johanniter Krankenhaus, Bonn, Nordrhein-Westfalen, Germany.
Mark CoburnDepartment of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany.
Christian PutensenDepartment of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany.
Christina Katharina WeisheitDepartment of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany.
University Hospital Bonn · DEJohannes Gutenberg University Mainz · DEJohanniter-Krankenhaus Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sepsis is a leading cause of death worldwide, despite the use of multimodal therapies. Common antibiotic regimens are being affected by a rising number of multidrug-resistant pathogens, and new therapeutic approaches are therefore needed. Antibiotics have immunomodulatory properties which appear to be beneficial in the treatment of sepsis. We hypothesized that the last-resort antibiotics vancomycin (VAN) and daptomycin (DMC) modulate cell migration, phagocytosis, and protein cytokine levels in a murine model of lipopolysaccharide (LPS)-induced sepsis. Ten to twelve-week-old C57BL/6 mice (

Indexed as

AnimalsAnti-Bacterial AgentsCytokinesDaptomycinDendritic CellsImmunity, InnateLeukocyte CountLipopolysaccharidesMacrophages, PeritonealMaleMiceMice, Inbred C57BLPeritoneal CavityPhagocytosisSepsisVancomycinAnti-Bacterial AgentsCytokinesDaptomycinLipopolysaccharidesVancomycinantibioticsdendritic cellsimmunomodulatory propertiesmacrophagesneutrophilsphagocytosis

Identifiers

PMID34296627
PMCPMC8312155
OpenAlexW3183819203

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.