Evidence map›Paper›PMID 34296492›Full record

SynthesisHuman brain mapping2021

Structural and functional brain alterations in anorexia nervosa:A multimodal meta-analysis of neuroimaging studies.

Ting Su, Jiaying Gong, Guixian Tang, Shaojuan Qiu, Pan Chen, Guanmao Chen, Junjing Wang, Li Huang, Ying Wang

Open access · goldAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 7 pooled it
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 7 syntheses or guidelines pooled it, 78 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Ting SuMedical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou, China.ORCID 0000-0003-3935-5821
Jiaying GongInstitute of Molecular and Functional Imaging, Jinan University, Guangzhou, China.
Guixian TangMedical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou, China.
Shaojuan QiuMedical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou, China.
Pan ChenMedical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou, China.
Guanmao ChenMedical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou, China.
Junjing WangDepartment of Applied Psychology, Guangdong University of Foreign Studies, Guangzhou, China.
Li HuangMedical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou, China.
Ying WangMedical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou, China.ORCID 0000-0002-0388-4177
Jinan University · CNFirst Affiliated Hospital of Jinan University · CNGuangdong University of Foreign Studies · CNSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anorexia nervosa (AN) is a complex psychiatric disorder with poorly understood etiology. Numerous voxel-based morphometry (VBM) and resting-state functional imaging studies have provided strong evidence of abnormal brain structure and intrinsic and functional activities in AN, but with inconsistent conclusions. Herein, a whole-brain meta-analysis was conducted on VBM (660 patients with AN, and 740 controls) and resting-state functional imaging (425 patients with AN, and 461 controls) studies that measured differences in the gray matter volume (GMV) and intrinsic functional activity between patients with AN and healthy controls (HCs). Overall, patients with AN displayed decreased GMV in the bilateral median cingulate cortex (extending to the bilateral anterior and posterior cingulate cortex), and left middle occipital gyrus (extending to the left inferior parietal lobe). In resting-state functional imaging studies, patients with AN displayed decreased resting-state functional activity in the bilateral anterior cingulate cortex and bilateral median cingulate cortex, and increased resting-state functional activity in the right parahippocampal gyrus. This multimodal meta-analysis identified reductions of gray matter and functional activity in the anterior and median cingulate in patients with AN, which contributes to further understanding of the pathophysiology of AN.

Indexed as

Anorexia NervosaCerebral CortexNeuroimagingHumansanorexia nervosameta-analysismultimodalresting-state functional imagingvoxel-based morphometry

Identifiers

PMID34296492
PMCPMC8449099
OpenAlexW3183649366

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.